Faculty Biography

Karen Posey

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Education:

BS, Botany: Louisiana Tech University, Ruston, Louisiana

MS, Plant Physiology: Texas A & M University, College Station, Texas

PhD, Biochemistry: University of Houston, Houston, Texas

Clinical and Research Interests:

1.  

Publications (selected):

• Abstracts

• Posey, K.L., Yang, Y., Bales E., Veerisetty A., Haynes R, Sharan S., and Hecht J.T.: Skeletal Phenotype of Mice Overexpressing Mutant Human COMP. International Workshop on the Skeletal Growth Plate Poster Presentation, Portland, Oregon, 2006.
• Posey, K.L., Davies, S., Sandell, L.J., and Hecht, J.T.: Human Cartilage Oligomeric Matrix Protein (COMP) Promoter Expression. FASEB Thrombospondins and Other Modulatory Adhesion Molecules in Tissue Organization and Homeostasis Poster Presentation, Pine Mountain, GA 2004.
• Posey, K.L. and Gimble, F.S.: Identification of a DNA Binding Loop in PI-SceI and the Effect of Divalent Metal Cations on DNA Binding. Structural Biology Conference Poster Presentation, Galveston, Texas, 2001.
• Posey, K.L. and Gimble, F.S.: Localization of the Residues in PI-SceI that Contact the Phosphate Backbone of the Recognition Sequence. Lost Pines Molecular Biology Conference Poster Presentation, Smithville, Texas, 2000.
• Posey, K.L., Roman, G., He, J., Davis, R. L., and Hardin, S.: Genetic and molecular characterization of eIF-5A in Drosophila. Lost Pines Molecular Biology Conference Poster Presentation. Smithville, Texas 1999.
• Posey, K.L., Jones, L.B., Hardin, S.H., and Hardin, P.E.: Analysis of an adult Drosophila cDNA brain library. Cold Spring Harbor Drosophila Neurobiology Conference Poster Presentation, Cold Spring Harbor, New York, 1998.
• Posey, K.L., Flagler, R.B., Rumpho, M.E.: A study of the effect of ozone and antioxidants on photosynthetic parameters of loblolly pine. American Society of Plant Physiology Poster Presentation, Charlotte, North Carolina, 1995.

• Referred Original Articles

• Posey, K.L., Davies, S., Sandell, L.J., and Hecht, J.T.: Human Cartilage Oligomeric Matrix Protein (COMP) Promoter Expression. Matrix Biology 24(8):539-49, 2005.
• Posey, K.L., Koufopanou, V., Burt, A., and Gimble, F.S.: Evolution of Divergent DNA Recognition Specificities in VDE Homing Endonucleases from Two Yeast Strains. Nucleic Acids Research 32(13):3947-56, 2004.
• Gimble, F., Posey, K.L., and Moure, C.: Assessing the Plasticity of DNA Target Site Recognition of the PI-SceI Homing Endonuclease Using a Bacterial Two-Hybrid Selection System. Journal of Molecular Biology 334(5):993-1008, 2003.
• Posey, K.L. and Gimble, F.S.: Insertion of a reversible redox switch into a rare-cutting DNA endonuclease. Biochemistry 41(7): 2184-90, 2002.
• Provisional Patient filed on the technology described in the above work.

• Referred Original Articles

• Posey, K.L., Jones, L.B., Cerda, R., Bajaj, M., Huynh, T., Hardin, P.E., and Hardin, S.H.: Survey of Transcripts in the Adult Drosophila Brain. Genome Biology 2(3): research0008.1-0008.16, 2001.
• Allen, B.A., Uhlmann, F., Gaur, L.K., Mulder, B.A., Posey, K.L., Jones, L.B., and Hardin, S.H.: DNA recognition properties of the N terminal DNA binding domain within the large subunit of replication factor C. Nucleic Acids Research 26:3877 3882, 1998.

• Invited Articles

• Posey, K.L., Hayes, E., Haynes, R., and Hecht, J.T.: Role of TSP-5/COMP in Pseudoachondroplasia. The International Journal of Biochemistry & Cell Biology, 36(6) 1005-12, 2004.

 

Location & Contact

6431 Fannin Street
MSB 3.020
Houston, Texas 77030
713-500-5757 (Voice)

Faculty Biography

• Karen Posey
  Instructor
• Department of Pediatrics
  Division of Genetics
• University of Texas-Houston Medical School
  6431 Fannin Street, MSB 3.134
  Houston, Texas 77030
• phone: (713) 500-5763
  e-mail: Karen.Posey@ uth.tmc.edu