Department of Pediatrics
Department of Pediatrics
The Department of Pediatrics

Faculty Biography

The Department of Pediatrics at the University of Texas Medical School at Houston is dedicated to improving the health and welfare of all infants, children, and adolescents.


Felix R. Shardonofsky, M.D.

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Education:

B.S., Colegio Nacional Bartolomé Mitre, Buenos Aires, Argentina, 1965

M.D., University of Buenos Aires School of Medicine, Buenos Aires, Argentina, 1972

Residency, Hospital de Niños Dr. Ricardo Gutierrez, Buenos Aires, Argentina, 1972 - 1975

Fellowship, Meakins-Christie Laboratories, McGill University, Montreal, Canada, 1987 - 1990

Fellowship, The Children’s Hospital of Philadelphia, University of  Pennsylvania, Philadelphia, Pennsylvania, 1990 - 1992

Residency, (PL3) General Pediatrics, Department of Pediatrics, The Children’s Hospital of Philadelphia 1992 - 1993

Clinical and Research Interests:

  1. Pediatric Pulmonary Hypertension
  2. Asthma and pediatric airway disease
  3. Pulmonary mechanics, mechanisms of airway hyperresponsiveness
  4. Exercise physiology
  5. Respiratory disease associated with neuromuscular disorders

Publications (selected):

  • Hanania NA, Singh S, El-Wali R, Flashner M, Franklin AE, Garner WJ, Dickey BF, Parra S, Ruoss S, Shardonofsky F, O’connor BJ, Page C, Bond RA.  The Safety and effects of the beta-blocker, nadolol, in mild asthma: An open-label pilot study.  Pulm Pharmacol Ther. 2008; 21 (1): 134-141.  Epub 2007, Jul 17.
  • Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA.  Changes in beta(2)-adrenoceptor and other signaling proteins produced by chronic administration of ‘beta-blockers’ in a murine asthma model.  Pulm Pharmacol Ther. 2008; 21 (1): 115-124.  Epub 2007, Jul 14.
  • Chen B, Liu G, Shardonofsky F, Dowell M, Lakser O, Mitchell RW, Fredberg JJ, Pinto LH, Solway J.  Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J versus A/J mice.  J Appl Physiol 2006; 101: 245-255.
  • Shardonofsky FR, Capetanaki Y, Boriek AM.  Desmin modulates lung elastic recoil and airway responsiveness.  Am J Phyiol Lung Cell Mol Physiol 2006; 295: L890-L906.
  • Suell MN, Bezold LI, Okcu F, Mahoney DH Jr, Shardonofsky F, Mueller BU.  Increased pulmonary artery pressures among adolescents with sickle cell disease.  Journal of Pediatr Hematol Oncol 2005; 27: 654-658.
  • Callaerts-Vegh Z, Evans KLJ, Dudeluka N, Cuba, Knoll B, Callaerts PKF, Shardonofsky FR, Bond RA..  Effects of acute and chronic administration of β-adrenoceptor ligands on airway function in a murine model of asthma.  Proc Natl Acad Sci USA 2004; 101: 4948-4953.
  • Lee SH, Prince JE, Rais M, Kheradmand F, Shardonofsky F, Lu H, Beaudet AL, Smith CW, Soong L, Corry DB.  Differential requirement for CD18 in T-helper effector homing.  Nat Med 2003; 10: 1281-1286
  • Evans KLJ, Bond RA, Corry DB, Shardonofsky FR.  Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma.  J Appl Physiol 2003; 94: 245-252.
  • Kanwar S, Smith CW, Shardonofsky FR, Burns AL. The role of Mac-1 (CD11b/CD18) in antigen-induced airway eosinophilia in mice. Am J Respir Cell Mol Biol 2001, 25: 170-177.
  • Gomez RFM, Shardonofsky FR, Eidelman DH, Bates JHT. Respiratory mechanics and lung development in the rat from early age to adulthood. J Appl Physiol. 2001, 90:1631-1638.
  • Shardonofsky FR, Officer T, Boriek AM, Wilson TA, Rodarte JR.  Effects of airway smooth muscle activation on axial mechanical properties of excised canine bronchi. J Appl Physiol. 2001, 90: 1258-1266.
  • Janahi IA, Shardonofsky FR, Elidemir O, Abu-Hassan MN, Fan LL, Larsen GL, Colasurdo GN. Recurrent milk aspiration produces changes in airway mechanics and lung eosinophilia in a murine model.  Ped Research 2000, 48(6):776-781.
  • Shardonofsky F, Vanzor III J, Barrios R, Leon K, Huston DP.  Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma.  J. Allergy Clinic Immunol. 1999, 104:215-221.
  • Shardonofsky F, Sato J, Eidelman DH.  Frequency dependence of pulmonary and chest wall mechanics in young and adult cats.  J. Appl. Physiol. 1994, 76:2037-2046.
  • Shardonofsky F, McDonough J, Grunstein MM.  Effects of positive end-expiratory pressure on lung tissue mechanics in rabbits.  J. Appl. Physiol. 1993, 75:2506-2513.
  • Shardonofsky F, Martin JG, Eidelman DH.  Effect of body posture on concentration-response curves to inhaled methacholine.  Am. Rev. Respir. Dis. 1992, 145:750-755.
  • Shardonofsky F, Perez-Chada D, Milic-Emili J.  Airway pressure during crying: An index of the respiratory muscle force in infants with neuromuscular disease.  Pediatr. Pulmonol. 1991, 10:172-177.
  • Shardonofsky F, Skaburskis M, Sato J, Zin WA, Milic-Emili J.  Effects of volume history and vagotomy on pulmonary and chest wall mechanics in cats.  J. Appl. Physiol. 1991, 71:498-508.
  • Shardonofsky F, Sato J, Bates JHT.  Effect of gas exchange on hysteresis of respiratory pressure-volume curves.  Reply letter to the editor.  J. Appl. Physiol. 1990, 60:2317-2318.
  • Sato J, Davey BLK, Shardonofsky F, Bates JHT.  Low-frequency respiratory system resistance in the normal dog during mechanical ventilation.  J. Appl. Physiol. 1991, 70:1536-1543.
  • Romero PV, Sata J, Shardonofsky F, Bates JHT.  High-frequency characteristics of respiratory mechanics determined by flow interruption.  J. Appl. Physiol. 1990, 69:1682-1688.
  • Shardonofsky F, Sato J, Bates JHT.  Quasi-static pressure-volume hysteresis in the canine respiratory system in vivo.  J. Appl. Physiol. 1990, 68:2230-2236.
  • Skaburskis M, Shardonofsky F, Milic-Emili J.  Effect of serotonin on expiratory pulmonary resistance in cats.  J. Appl. Physiol. 1990, 68:2419-2425.
  • Alvarez AR, Shardonofsky F.  Severe asthmatic crisis in children.  Bol. Med. Hosp. Infant Mex. 1989, 46:251-258.
  • Skaburskis M, Shardonofsky F, Milic-Emili J.  Flow and volume dependence of expiratory resistance in anesthetized cats.  J. Appl. Physiol. 1989, 67:1013-1019.
  • Bates JHT, Shardonofsky F, Steward DE.  The low-frequency dependence of respiratory system resistance and elastance in the normal dog.  Respiration Physiol. 1989, 78:369-382.
  • Shardonofsky F, Perez Chada D, Carmuega E, Milic-Emili J.  Airway pressures during crying in healthy infants.  Pediatr. Pulmonol. 1989, 6:14-18.
  • Shardonofsky F, Lejarraga H, Macri C, Alvarez A.  Radiometric lung growth in children with cystic fibrosis.  Bol. Med. Hosp. Infant Mex. 1986, 43:504-509.
  • Shardonofsky F, Grinstein S, Vilar M, Alvarez A.  Etiology of multifocal pneumonia in children. Revista del Hospital de Niños, Buenos Aires 1979, 84:71-76.
  • Shardonofsky F, Alvarez A, Grinstein S, Bayley Bustamante G.  Etiology of pleuropulmonary infections in children.  Medicine, Buenos Aires 1979, 39:9-15.
  • Shardonofsky F, Alvarez A.  Bronchiolitis.  Revista del Hospital de Niños, Buenos Aires 1976, 70:79-84.

Book Chapters

  • Joseph R. Rodarte, Felix R. Shardonofsky.  Respiratory System Mechanics.  In:  Textbook of Respiratory Medicine.  Editors:  JF Murray, JA Nadel, RJ Mason, and HA Boushey, Jr.  WB Saunders Co, 2000, chapter 4, pages 91-117.
  • Shardonofsky FR.  Heart Failure in Pediatric Patients.  In: Heart Failure in Children and Young Adults: From Molecular Mechanisms To Medical Management.  Editors: AC Chang and J Towbin.  Elsevier, 2006, chapter 28, pages 398-415. 

Faculty Biography

  • Felix R. Shardonofsky, MD
    Professor
  • Department of Pediatrics
    Director, Division of Pulmonary Medicine
  • University of Texas-Houston Medical School
    6431 Fannin Street, MSB 3.228
    Houston, Texas 77030
  • phone: (713) 500-5650
    fax: (713) 500-0588
    e-mail: Felix.Shardonofsky@ uth.tmc.edu
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