The University of Texas Health Science Center at Houston The University of Texas Health Science Center at Houston
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  Scleroderma Foundation   |
  Scleroderma-related Publications Since Inception of the Center of  Research Translation (formerly the SCOR)
  1. Tan F, Stivers DN, Chakraborty R, Foster MW, Howard RF, Milewicz DM, Arnett FC: Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population. Arthritis Rheum. 1998, 41:1729-1737  PubMed

  2. Tan F, Stivers DN, Arnett FC, Chakraborty R, Howard RF, Reveille JD: HLA haplotypes and microsatellite polymorphisms in and around the MHC region in a Native American population with a high prevalence of scleroderma (systemic sclerosis). Tissue Antigens 1999, 53:74-80  Publication

  3. Tan FK, Arnett FC, Stephan S, Sinichiro S, Mirachi A, Speira H, Takeshi S, Shoichi O, LeRoy C, Postlethwaite AE, Bona C: Autoantibodies to the extra-cellular matrix microfibrillar protein, fibrillin-1 in patients with scleroderma and other connective tissue diseases. J Immunol 1999, 163: 1066-1072  Publication

  4. Arnett FC, Tan FK, Uziel Y, Krafchik BR, Laxer RM, Antohi S, Bona CA: Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1 in patients with localized scleroderma. Arthritis Rheum 1999, 42:2656-2659  PubMed
     
  5. Tan FK, Arnett FC. Genetic factors in the etiology of systemic sclerosis and Raynaud phenomenon. Curr Opin Rheumatol. 2000 12:511-9 Publication

  6. Zhou X, Tan FK, Stivers DN, Arnett FC: Microsatellites and intragenic polymorphisms of transforming growth factor beta and platelet derived growth factor and their receptor genes in Native Americans with systemic sclerosis (scleroderma): a preliminary genetic analysis showing no genetic association. Arthritis Rheum 2000, 43: 1068-1073  PubMed

  7. Tan FK, Arnett, FC, Reveille JD, Ahn, C, Antohi, S, Kasturi, K., Sasaki, T, Nishioka, Bona CA: Autoantibodies to fibrillin-1 in systemic sclerosis: ethnic differences in antigen recognition and lack of correlation with specific clincal features or HLA alleles. Arthritis Rheum 2000, 43: 2464-24  PubMed

  8. Tan FK, Wang N, Kuwana M, Chakraborty R, Bona C, Milewicz D, Arnett FC: Association of fibrillin-1 single nucleotide polymorphisms (SNP) haplotypes with systemic sclerosis in Native American and Japanese populations. Arthritis Rheum 2001, 44: 893-901  PubMed

  9. Guo D, Tan FK, Cantu A, Plon SE, Milewicz: FBN1 exon 2 splicing error in a patient with Marfan syndrome. Am J Med Genet 2001, 101: 130-134  Publication

  10. Wallis DD, Tan FK, Kielty CM, Arnett FC, Milewicz DM: Abnormalities in fibrillin-1 containing microfibrils in dermal fibroblasts cultures from patients with systemic sclerosis (scleroderma). Arthritis Rheum 2001, 44:1855-1864  PubMed

  11. Tew MB, Reveille JD, Arnett FC, Friedman AW, McNearney T, Fischbach M, Ahn C, Tan FK: Glutathione-S-transferase genotypes in systemic sclerosis. Genes Immunity 2001, 2:236-238  Publication

  12. Johnson RW, Reveille, JD, McNearney T., Fischbach M., Friedman AF, Ahn C, Arnett FC, Tan FK: Lack of association of a functionally relevant single nucleotide polymorphism in the metalloproteinase 1 promoter with systemic sclerosis, Genes Immunity 2001, 2:273-275  Publication

  13. Zhou XD, Tan FK, Xiong M, Milewicz DM, Feghali C, Fritzler M, Arnett FC: Systemic Sclerosis (Scleroderma) - specific autoantigen genes are selectively over-expressed in scleroderma fibroblasts, J Immunol 2001, 167:7126-7133  Publication

  14. Arnett FC, Cho M, Chatterjee S, Aguilar MB, Reveille JD, Mayes MD. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis Rheum. 2001 44:1359-1362 PubMed

  15. Reveille JD, Fischbach M, McNearney T, Friedman AW, Aguilar MB, Lisse J, Fritzler MJ, Ahn C, Arnett FC; GENISOS Study Group. Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants. Semin Arthritis Rheum. 2001 30:332-46 Publication

  16. Denton CP, Zheng B, Shiwen X, Zhang Z, Bou-Gharios G, Eberspaecher H, Black CM, de Crombrugghe B. Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice. Arthritis Rheum. 2001 44:712-22 PubMed

  17.  Tew MB, Arnett FC, Reveille JD, Tan FK: Mutations of the bone morphogenetic protein receptor 2 (BMPR2) are not found in patients with pulmonary hypertension and underlying connective tissue disease. Arthritis Rheum 2002, 46:2829-2830 Publication

  18. Zhou XD, Tan FK, Reveille JD, Wallis D, Milewicz DM, Ahn C, Wang A, Arnett FC: Association of novel polymorphims with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma.. Arthritis Rheum 2002, 46: 2990-2999  Publication

  19. Kodera T, Tan FK, Sasaki T, Arnett FC, Bona CA. Association of 5'-untranslated region of the Fibrillin-1 gene with Japanese scleroderma. Gene 2002; 297:61-67  Publication

  20. Johnson RW, Tew MB, Arnett FC. The genetics of systemic sclerosis. Curr Rheumatol Rep. 2002 4:99-107 PubMed

  21. Ahmed SS, Tan FK, Arnett FC. The complex genetics of scleroderma. Am J Med. 2002 112:584-586 Publication

  22. Arnett FC: Systemic sclerosis (scleroderma), in Molecular Pathology of Autoimmunity, 2nd Edition. Edited by AN Theofilopoulos and CA Bona, Taylor and Francis, New York, 2002, pp 453-469.

  23. Zhou X, Tan FK, Wang, Chakraborty R, Arnett FC:Genome-wide association study for systemic sclerosis susceptibility regions in a Native American population with a high disease prevalence. Arthritis Rheum 2003, 48: 2585-2592  Publication

  24. Tan FK, Tercero G, Wang N, Chakraborty R, Arnett FC. Association of fibrillin-1 single nucleotide polymorphisms (SNP) haplotypes with systemic sclerosis in Native American and Japanese populations: Examination of biologically relevant candidates around FBN1, Arthritis Rheum, 2003 48:3295-3296  Publication

  25. Reveille JD. Ethnicity and race and systemic sclerosis: how it affects susceptibility, severity, antibody genetics, and clinical manifestations.  Curr Rheumatol Rep. 2003 ;5:160-167 PubMed

  26. Ho KT, Reveille JD. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther. 2003 5:80-93. Epub 2003 Feb 12  Publication

  27. Tan FK. Systemic sclerosis: the susceptible host (genetics and environment). Rheum Dis Clin North Am. 2003 29:211-37 PubMed

  28. Mayes MD. Scleroderma epidemiology. Rheum Dis Clin North Am. 2003 29:239-254 PubMed

  29. Mayes MD. Endothelin and endothelin receptor antagonists in systemic rheumatic disease. Arthritis Rheum. 2003 48:1190-9 Publication

  30. Mayes MD, Lacey JV Jr, Beebe-Dimmer J, Gillespie BW, Cooper B, Laing TJ, Schottenfeld D. Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum. 2003 48 :2246-55 Publication

  31. Reveille JD, Solomon DH; American College of Rheumatology Ad Hoc Committee of Immunologic Testing Guidelines. Evidence-based guidelines for the use of immunologic tests: anticentromere, Scl-70, and nucleolar antibodies. Arthritis Rheum. 2003 49:399-412   Publication

  32. Ahmed SS, Tan FK. Identification of novel targets in scleroderma: update of population studies, cDNA arrays, SNP analysis, and mutations. Curr Opin Rheumatol. 2003 15:766-71 Publication

  33. Planque S, Zhou Y, Nishiyama Y, Sinha M, O’Connor-McCourt M, Arnett F, Paul S: Autoantibodies to the epidermal growth factor receptor in systemic sclerosis, lupus and autoimmune mice. FASEBJ 2003 17: 136-143, 2003 Publication

  34. Mayes MD, O'Donnell D, Rothfield NF, Csuka ME. Minocycline is not effective in systemic sclerosis: results of an open-label multicenter trial. Arthritis Rheum. 2004 50:553-557 Publication

  35. Wang N, Zhou X, Tan FK, Foster MW, Arnett FC, Chakraborty R: Genetic signatures of pre-expansion bottleneck in the Choctaw population of Oklahoma. Am J Phys Anthropol 2004, 124:373-379  Publication

  36. Wallis DD, Tan FK, Keasler R, Milewicz DM. Fibrillin-1 abnormalities in dermal fibroblast cultures from first degree relatives of patients with systemic sclerosis (Scleroderma). Arthritis Rheum 2004, 50:329-332 Publication 

  37. Cepeda EJ, Reveille JD. Autoantibodies in systemic sclerosis and fibrosing syndromes: clinical indications and relevance. Curr Opin Rheumatol. 2004 16:723-32  Publication

  38. Arnett FC, Reveille JD, O’Hanlon TP. HLA-DRB1 alleles in a Caucasian population from Houston USA. Hum Immunol 2004 65:1238-1241  Publication

  39. Zhou X, Dimachkie MM, Xiong M, Tan FK, Arnett FC: cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies. Med Sci Monit 2004 10: BR191-BR197  Publication

  40. Zhou X, Tan FK, Guo X, Wallis D, Milewicz DM, Xue S, Arnett FC. Short interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor b1 in cultured normal human fibroblasts. Arthritis Rheum 2005 52:257-261 Publication

  41. Basu D, Reveille JD. Anti-Scl70. Autoimmunity 2005,  38:65-72 PubMed

  42. Tan FK, Hildebrand BA, Lester M, Stivers DN, Pounds S, Zhou X, Wallis DD, Milewicz DM, Reveille JD, Mayes MD, Jin L, Arnett FC. Classification analysis of the transcriptosome of non-lesional cultured dermal fibroblasts from scleroderma patients with early disease. Arthritis Rheum 2005, 52:865-876  Publication  Supplemental data

  43. Assasi S, Reveille JD, Arnett FC, Mayes MD, McNearny T, Fischbach M, Tan FK. Polymorphisms of the endothelial nitric oxide synthase and angiotensin-converting enzyme show no association with systemic sclerosis. Am J Med  2005, 118: 907-911 Publication

  44. Zhou X, Tan FK, Wallis D, Bona C, Milewicz DM, Arnett F: Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF beta pathway and recapitulate the “scleroderma phenotype” J Immunol, 2005, 175:4555-4560 Publication

  45. Xiong M, Arnett FC, Feghali-Bostwick CA, Zhou X. A systems biology approach to complex diseases. FEBS Lett, 2005, 579:5325-5332 Publication

  46. Zhou XD, Tan FK, Xiong M, Arnett FC, Feghali-Bostwick C. Clinically discordant scleroderma monozygotic twins show concordance for fibroblast gene expression profiles. Arthritis Rheum, 2005, 52:3305-3314  Publication  Supplemental data

  47. Assassi S, Tan FK. Genetics of scleroderma: update on SNP analysis and microarrays. Current Opin Rheumatol, 2005, 17:761-767 Publication

  48. Tan FK, Zhou X, Mayes MD, Gourh P, Guo X, Marcum C, Jin L, Arnett FC. Signatures of differentially regulated interferon gene expression and vasculotropism in the peripheral blood cells of systemic sclerosis patients. Rheumatology (Oxford),  2006, 45: 694-702  Publication Supplemental data

  49. Gardner H, Shearstone J, Bandaru R, Crowell T, Lynes M, Trojanowska M,  Pannu J, Kubo M, Smith E, Jablonlska S, Blaszczyk, Tan FK, Mayes MD.  Gene profiling of scleroderma skin reveals robust signatures of disease which are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum  2006, 43:1961-1973 Publication

  50. Tan, F. K.  Autoantibodies against PDGF Receptor in Scleroderma.  N Engl J Med 2006, 354: 2709-2711 Publication

  51. Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE, Arriola E, Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel DE, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M; Scleroderma Lung Study Research Group. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med, 2006 354:2655-2666 Pubmed

  52. Ahmed SS, Tan FK, Arnett FC, Jin L, Geng YJ. Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies. Arthritis Rheum, 2006 54:2250-2262 Publication

  53. Zhou X, Tan FK, Guo X, Arnett FC. Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts form the skin of patients with scleroderma. Arthritis Rheum, 2006 54:2626-2631 Publication

  54. Arnett, FC.  Is scleroderma an autoantibody mediated disease? Curr Opin Rhematol, 2006 18: 579-581 Publication

  55. Zhou XD, Xiong M, Tan FK, Guo XJ, Arnett FC. SPARC, an upstream regulator of connective tissue growth factor to transforming growth factor beta stimulation. Arthritis Rheum, 2006 54:3885-3889 Publication

  56. Gourh P, Tan FK,  Assassi S,  Ahn CW. McNearney TA, Fischbach M,  Arnett FC, Mayes MD.  Association of the PTPN22 R620W polymorphism with topoisomerase I and centromere autoantibody positive systemic sclerosis. Arthritis Rheum 2006, 54:3945-2953 Publication

  57. Sonnylal S, Denton CP, Zheng B, Keene DR, He R, Adams HP, Vanpelt CS, Geng YJ,Deng JM, Behringer RR,de Crombrugghe B. Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum. 2007 56:334-44 Publication

  58. Mcnearny TA, Reveille JD, Fischbach M, Friedman AF, Lisse JR, Goel N, Tan FK,  Zhou X,  Ahn  C, Feghali-Bostwick CA, Fritzler M, Arnett FC, Mayes MD. Pulmonary involvement in systemic sclerosis: Associations with genetic, serologic, sociodemographic, and behavioral factors. Arthritis Care Res, 2007 57: 318-326 Publication

  59. Alkassab F, Gourh P, Tan FK, McNearny T, Fischbach M, Ahn C, Arnett FC, Mayes MD. An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis. Rheumatology (Oxford), 2007 Publication

  60. Assassi S, Arnett FC, Reveille JD, Gourh P, Mayes MD. Clinical, immunologic, and genetic features of familial systemic sclerosis. Arthritis Rheum, 2007 56: 2031 - 2037 Publication

  61. Goruh P, Mayes MD, Arnett FC. CTGF polymorphism associated with systemic sclerosis. N Engl J Med, 2008 358:308-309 Publication

  62. Agarwal SK, Tan FK, Arnett FC. Genetics and Genomic studies in scerloderma (systemic sclerosis). Rheum Dis Clin N Am, 2008 34:17-40 Publication

  63. Xiong M, Arnett FC, Guo X, Xiong H, Zhou X. Differential dynamic properties of scleroderma fibroblasts in response to environmental stimuli. PLoS ONE, 2008 3:e1693 Publication

  64. Kim D, Peck A, Santer D, Patole P, Schwartz S. Molitor JA, Arnett FC, Elkon K. Induction of interferon-a  by scleroderma sera containing autoantibodies to topoisomerase I: Association of higher interferon-a activity with lung fibrosis. Arthritis Rheum, 2008 58:2174-2182 Publication