Description of the problem:

Number of classes: 2
Number of genes: 8324
Number of genes that passed filtering criteria: 8324
Number of investigated pathways: 211 BioCarta and 77 KEGG (288 total)
Random variance model was used


Pathways which discriminate among classes:

Table - Sorted by p-value of the LS permutation test.
The first 4 pathways are significant at the nominal 0.01 level of the LS permutation test or KS permutation test

Pathway id Pathway description Number of genes LS Permutation p-value KS Permutation p-value
1Kegg: hsa00600Sphingoglycolipid Metabolism90.004480.00287
2BioCarta: h_granulocytesPathwayAdhesion and Diapedesis of Granulocytes50.024920.00951
3BioCarta: h_myosinPathwayPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase50.09330.00956
4BioCarta: h_gabaPathwayGamma-aminobutyric Acid Receptor Life Cycle50.173920.00926



Table Significant pathways consist of the following genes:


Pathway idPathway desciptionUnique idDescriptionCloneGB accUG clusterGene symbolGeometric mean of ratios
( Disease / Normal )
p-value
1hsa00600Sphingoglycolipid MetabolismH000076_01UDP-glucose ceramide glucosyltransferaseH000076_01D50840152601UGCG0.810.01527
2hsa00600Sphingoglycolipid MetabolismH001062_01N-acylsphingosine amidohydrolase (acid ceramidase)H001062_01U7006375811ASAH0.7610.00155
3hsa00600Sphingoglycolipid MetabolismH001185_01Arylsulfatase AH001185_01NM_00048788251ARSA0.9040.14918
4hsa00600Sphingoglycolipid MetabolismH001229_01Arylsulfatase E (chondrodysplasia punctata 1)H001229_01X8357374131ARSE1.0790.26811
5hsa00600Sphingoglycolipid MetabolismH002064_01Galactosidase, beta 1H002064_01M3442379222GLB10.8160.01277
6hsa00600Sphingoglycolipid MetabolismH007128_01Cerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferaseH007128_01D8866717958CST1.1050.2026
7hsa00600Sphingoglycolipid MetabolismH008567_01Sialidase 1 (lysosomal sialidase)H008567_01AF040958118721NEU10.8330.01207
8hsa00600Sphingoglycolipid MetabolismH012673_01Serine palmitoyltransferase, long chain base subunit 2H012673_01AB01109859403SPTLC21.0340.55588
9hsa00600Sphingoglycolipid MetabolismH014980_01Glucosidase, beta; acid (includes glucosylceramidase)H014980_01NM_000157282997GBA0.8820.09493
10h_granulocytesPathwayAdhesion and Diapedesis of GranulocytesH002233_01Selectin P ligandH002233_01NM_00300679283SELPLG1.1640.02755
11h_granulocytesPathwayAdhesion and Diapedesis of GranulocytesH002931_01Selectin L (lymphocyte adhesion molecule 1)H002931_01M2528082848SELL0.9420.32569
12h_granulocytesPathwayAdhesion and Diapedesis of GranulocytesH002944_01Interleukin 8H002944_01M17017624IL81.4990.02976
13h_granulocytesPathwayAdhesion and Diapedesis of GranulocytesH003221_01Lymphotoxin beta receptor (TNFR superfamily, member 3H003221_01L042701116LTBR0.8560.08611
14h_granulocytesPathwayAdhesion and Diapedesis of GranulocytesH003784_01Intercellular adhesion molecule 1 (CD54), human rhinovirus receptorH003784_01M24283168383ICAM10.7980.01573
15h_myosinPathwayPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphataseH001367_01Protein kinase C, alphaH001367_01X52479169449PRKCA0.8940.11314
16h_myosinPathwayPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphataseH003826_01Protein kinase C-like 1H003826_01U330532499PRKCL10.9210.28641
17h_myosinPathwayPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphataseH008350_01Myosin phosphatase, target subunit 2H008350_01AB007972130760MYPT20.8950.27031
18h_myosinPathwayPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphataseH010567_01Homo sapiens protein kinase C-alpha mRNA, partial 3' UTRH010567_01AF0355942798561.1170.17118
19h_myosinPathwayPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphataseH011336_01Guanine nucleotide binding protein (G protein), q polypeptideH011336_01U43083296261GNAQ1.1560.00709
20h_gabaPathwayGamma-aminobutyric Acid Receptor Life CycleH001660_01Dynamin 1H001660_01L07807166161DNM11.10.19358
21h_gabaPathwayGamma-aminobutyric Acid Receptor Life CycleH005952_01GephyrinH005952_01AB03780613405GPHN0.8970.1513
22h_gabaPathwayGamma-aminobutyric Acid Receptor Life CycleH007996_01GABA(A) receptor-associated proteinH007996_01NM_0072787719GABARAP0.8920.02784
23h_gabaPathwayGamma-aminobutyric Acid Receptor Life CycleH013966_01Hypothetical proteinH013966_01AJ01191684359HSA0119161.0560.2844
24h_gabaPathwayGamma-aminobutyric Acid Receptor Life CycleH015514_01Hypothetical protein MGC2941H015514_01NM_024297288217MGC29411.0710.26215


Date and time of the analysis:

Name of the project file: Project.xls
Time of the analysis: Thu Apr 28 09:07:44 2005