VEGFB COL18A1 FLT1 VEGF contraction apoptosis ROR1 NRCAM secretion assemble maturation metabolism CREG cell survival differentiation proliferation depolymerize mitogenesis amplify endocytosis integrity angiogenesis phospholipase C map kinase catabolism growth rate actin NPC1 ARK5 PGS1 TRAP1 NSE1 NTE RAC2 PON2 INPP1 HNRPC GYPC SLC40A1 DSP DSTN AKR1B1 ADH5 NSMAF AKR1C2 PFKFB3 KIF4A AKAP12 HNMT MAFG DAF LSAMP ALDH2 SGK NEDD4 CD44 COMP TP53 SERPINE1 MT1A

FIGURE 3A. Analysis for common cellular targets.  First 71 genes differentially expressed during class comparisons was used in this analysis (nominal p=0.006). PathwayAssist (Ariadne Genomics, Rockville, MD) a software tool for biological pathway analysis was used. It relies on ResNet, a database specifically targeted at the extracting data from the language of scientific abstracts from PubMed in order to identify relationships among genes, visualize pathways, gene regulation networks and protein interactions. This analysis used ResNet 3.0 (Medline August, 24,2004). To simplify the network, genes that could not be linked together were removed. Genes that are increased in SSc fibroblasts are colored red, and genes that are decreased colored pink. Cellular processes that  inserted by Pathway Assist to link the genetic networks are colored gray. The boxes on the arrows are hyperlinks indicating relationships of the genes and targets.