| Number of investigated GO categories: 1200 |
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| GO
categories which discriminate among classes: |
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| Table - Sorted by p-value of the LS permutation test. |
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| The
first 12 GO categories are significant at the nominal 0.01 level of the LS
permutation test or KS permutation test |
|
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|
| |
GO category |
GO description |
Number of genes |
LS Permutation p-value |
KS Permutation p-value |
|
| 1 |
5581 |
collagen |
18 |
0.00289 |
0.01794 |
|
| 2 |
5201 |
extracellular matrix structural
constituent |
35 |
0.00612 |
0.02334 |
|
| 3 |
776 |
kinetochore |
9 |
0.00655 |
0.00447 |
|
| 4 |
6401 |
RNA catabolism |
9 |
0.00701 |
0.14152 |
|
| 5 |
5520 |
insulin-like growth factor
binding |
7 |
0.00806 |
0.04783 |
|
| 6 |
4252 |
serine-type endopeptidase
activity |
33 |
0.01633 |
0.00489 |
|
| 7 |
8287 |
protein serine/threonine
phosphatase complex |
16 |
0.04178 |
0.00162 |
|
| 8 |
4295 |
trypsin activity |
25 |
0.04551 |
0.00922 |
|
| 9 |
43087 |
regulation of GTPase activity |
6 |
0.05519 |
0.00484 |
|
| 10 |
6687 |
glycosphingolipid metabolism |
6 |
0.20802 |
0.00758 |
|
| 11 |
30148 |
sphingolipid biosynthesis |
5 |
0.218 |
0.00791 |
|
| 12 |
6664 |
glycolipid metabolism |
8 |
0.24384 |
0.00228 |
|
|
| Table Significant GO categories consist of the following genes: |
|
|
| |
GO category |
GO desciption |
Qiagen Oligo ID |
Description |
GB acc |
UG cluster |
Gene symbol |
Geometric mean of ratios in Norm |
Geometric mean of ratios in SSc |
Fold difference of Geometric
means |
p-value |
| 1 |
5581 |
collagen |
H001909_01 |
Collagen, type IV, alpha 2 |
X05610 |
75617 |
COL4A2 |
0.774 |
1.455 |
1.88 |
0.16588 |
| 2 |
5581 |
collagen |
H001981_01 |
Collagen, type VI, alpha 3 |
X52022 |
80988 |
COL6A3 |
13.102 |
14.887 |
1.14 |
0.3969 |
| 3 |
5581 |
collagen |
H002090_01 |
Collagen, type XVI, alpha 1 |
M92642 |
26208 |
COL16A1 |
1.487 |
0.807 |
0.54 |
0.01286 |
| 4 |
5581 |
collagen |
H002160_01 |
Collagen, type V, alpha 2 |
Y14690 |
82985 |
COL5A2 |
2.909 |
7.335 |
2.52 |
0.02257 |
| 5 |
5581 |
collagen |
H002647_01 |
Collagen, type XV, alpha 1 |
L25286 |
83164 |
COL15A1 |
2.556 |
1.679 |
0.66 |
0.06883 |
| 6 |
5581 |
collagen |
H002655_01 |
Collagen, type VII, alpha 1
(epidermolysis bullosa, dystrophic, dominant and recessive) |
L02870 |
1640 |
COL7A1 |
1.353 |
1.381 |
1.02 |
0.90084 |
| 7 |
5581 |
collagen |
H002915_01 |
Collagen, type VIII, alpha 1 |
X57527 |
114599 |
COL8A1 |
1.699 |
4.652 |
2.74 |
0.00779 |
| 8 |
5581 |
collagen |
H002994_01 |
Collagen, type XVIII, alpha 1 |
AF018081 |
78409 |
COL18A1 |
1.233 |
1.081 |
0.88 |
0.55803 |
| 9 |
5581 |
collagen |
H003072_01 |
Collagen, type I, alpha 2 |
J03464 |
179573 |
COL1A2 |
2.917 |
9.772 |
3.35 |
0.00199 |
| 10 |
5581 |
collagen |
H003413_01 |
Lumican |
U21128 |
79914 |
LUM |
5.429 |
6.831 |
1.26 |
0.38015 |
| 11 |
5581 |
collagen |
H003504_01 |
Collagen, type I, alpha 1 |
Z74615 |
172928 |
COL1A1 |
1.499 |
1.334 |
0.89 |
0.5702 |
| 12 |
5581 |
collagen |
H003593_01 |
Collagen, type VI, alpha 2 |
AL096746 |
159263 |
COL6A2 |
11.306 |
8.367 |
0.74 |
0.19054 |
| 13 |
5581 |
collagen |
H006623_01 |
Homo sapiens clone HB-2 mRNA
sequence |
AF216077 |
48376 |
|
1.078 |
1.072 |
0.99 |
0.98024 |
| 14 |
5581 |
collagen |
H000708_01 |
Collagen, type XIX, alpha 1 |
D38163 |
89457 |
COL19A1 |
1.008 |
1.613 |
1.60 |
0.15001 |
| 15 |
5581 |
collagen |
H000774_01 |
Collagen, type VI, alpha 1 |
X15880 |
108885 |
COL6A1 |
7.419 |
14.402 |
1.94 |
0.01162 |
| 16 |
5581 |
collagen |
H012686_01 |
Collagen, type XIII, alpha 1 |
NM_005203 |
211933 |
COL13A1 |
3.087 |
6.268 |
2.03 |
0.12493 |
| 17 |
5581 |
collagen |
H015060_01 |
Smooth muscle cell-expressed and
macrophage conditioned medium-induced protein smag-64 |
NM_020351 |
283100 |
LOC57086 |
0.419 |
0.612 |
1.46 |
0.01543 |
| 18 |
5581 |
collagen |
H001198_01 |
Homo sapiens, alpha-1 (VI)
collagen |
M20776 |
25459 |
|
7.041 |
6.65 |
0.94 |
0.79953 |
| 19 |
5201 |
extracellular matrix structural
constituent |
H001909_01 |
Collagen, type IV, alpha 2 |
X05610 |
75617 |
COL4A2 |
0.774 |
1.455 |
1.88 |
0.16588 |
| 20 |
5201 |
extracellular matrix structural
constituent |
H001981_01 |
Collagen, type VI, alpha 3 |
X52022 |
80988 |
COL6A3 |
13.102 |
14.887 |
1.14 |
0.3969 |
| 21 |
5201 |
extracellular matrix structural
constituent |
H002090_01 |
Collagen, type XVI, alpha 1 |
M92642 |
26208 |
COL16A1 |
1.487 |
0.807 |
0.54 |
0.01286 |
| 22 |
5201 |
extracellular matrix structural
constituent |
H002143_01 |
Fibrillin 1 (Marfan syndrome) |
X63556 |
750 |
FBN1 |
8.277 |
5.989 |
0.72 |
0.1062 |
| 23 |
5201 |
extracellular matrix structural
constituent |
H002160_01 |
Collagen, type V, alpha 2 |
Y14690 |
82985 |
COL5A2 |
2.909 |
7.335 |
2.52 |
0.02257 |
| 24 |
5201 |
extracellular matrix structural
constituent |
H002196_01 |
Nidogen (enactin) |
M30269 |
62041 |
NID |
1.534 |
1.486 |
0.97 |
0.80662 |
| 25 |
5201 |
extracellular matrix structural
constituent |
H002647_01 |
Collagen, type XV, alpha 1 |
L25286 |
83164 |
COL15A1 |
2.556 |
1.679 |
0.66 |
0.06883 |
| 26 |
5201 |
extracellular matrix structural
constituent |
H002655_01 |
Collagen, type VII, alpha 1
(epidermolysis bullosa, dystrophic, dominant and recessive) |
L02870 |
1640 |
COL7A1 |
1.353 |
1.381 |
1.02 |
0.90084 |
| 27 |
5201 |
extracellular matrix structural
constituent |
H002915_01 |
Collagen, type VIII, alpha 1 |
X57527 |
114599 |
COL8A1 |
1.699 |
4.652 |
2.74 |
0.00779 |
| 28 |
5201 |
extracellular matrix structural
constituent |
H002994_01 |
Collagen, type XVIII, alpha 1 |
AF018081 |
78409 |
COL18A1 |
1.233 |
1.081 |
0.88 |
0.55803 |
| 29 |
5201 |
extracellular matrix structural
constituent |
H003066_01 |
Biglycan |
J04599 |
821 |
BGN |
3.118 |
3.278 |
1.05 |
0.87448 |
| 30 |
5201 |
extracellular matrix structural
constituent |
H003072_01 |
Collagen, type I, alpha 2 |
J03464 |
179573 |
COL1A2 |
2.917 |
9.772 |
3.35 |
0.00199 |
| 31 |
5201 |
extracellular matrix structural
constituent |
H003413_01 |
Lumican |
U21128 |
79914 |
LUM |
5.429 |
6.831 |
1.26 |
0.38015 |
| 32 |
5201 |
extracellular matrix structural
constituent |
H003504_01 |
Collagen, type I, alpha 1 |
Z74615 |
172928 |
COL1A1 |
1.499 |
1.334 |
0.89 |
0.5702 |
| 33 |
5201 |
extracellular matrix structural
constituent |
H003593_01 |
Collagen, type VI, alpha 2 |
AL096746 |
159263 |
COL6A2 |
11.306 |
8.367 |
0.74 |
0.19054 |
| 34 |
5201 |
extracellular matrix structural
constituent |
H004275_01 |
Elastin microfibril interface
located protein |
AL050138 |
63348 |
EMILIN |
1.261 |
1.004 |
0.80 |
0.16069 |
| 35 |
5201 |
extracellular matrix structural
constituent |
H005515_01 |
EGF-containing fibulin-like
extracellular matrix protein 2 |
AJ132819 |
6059 |
EFEMP2 |
5.651 |
4.95 |
0.88 |
0.56638 |
| 36 |
5201 |
extracellular matrix structural
constituent |
H006167_01 |
Mucin 4, tracheobronchial |
AJ242549 |
198267 |
MUC4 |
1.088 |
1.118 |
1.03 |
0.87749 |
| 37 |
5201 |
extracellular matrix structural
constituent |
H006182_01 |
Matrilin 3 |
AJ224741 |
278461 |
MATN3 |
1.019 |
0.762 |
0.75 |
0.04621 |
| 38 |
5201 |
extracellular matrix structural
constituent |
H006243_01 |
Matrilin 4 |
AJ007581 |
278489 |
MATN4 |
1.13 |
1.322 |
1.17 |
0.55955 |
| 39 |
5201 |
extracellular matrix structural
constituent |
H006623_01 |
Homo sapiens clone HB-2 mRNA
sequence |
AF216077 |
48376 |
|
1.078 |
1.072 |
0.99 |
0.98024 |
| 40 |
5201 |
extracellular matrix structural
constituent |
H000708_01 |
Collagen, type XIX, alpha 1 |
D38163 |
89457 |
COL19A1 |
1.008 |
1.613 |
1.60 |
0.15001 |
| 41 |
5201 |
extracellular matrix structural
constituent |
H000774_01 |
Collagen, type VI, alpha 1 |
X15880 |
108885 |
COL6A1 |
7.419 |
14.402 |
1.94 |
0.01162 |
| 42 |
5201 |
extracellular matrix structural
constituent |
H011464_01 |
Microfibrillar-associated
protein 3 |
AL049404 |
28785 |
MFAP3 |
1.662 |
1.851 |
1.11 |
0.59568 |
| 43 |
5201 |
extracellular matrix structural
constituent |
H012686_01 |
Collagen, type XIII, alpha 1 |
NM_005203 |
211933 |
COL13A1 |
3.087 |
6.268 |
2.03 |
0.12493 |
| 44 |
5201 |
extracellular matrix structural
constituent |
H000992_01 |
Fibulin 2 |
X82494 |
198862 |
FBLN2 |
19.293 |
19.864 |
1.03 |
0.92471 |
| 45 |
5201 |
extracellular matrix structural
constituent |
H013067_01 |
Amelogenin (Y chromosome) |
M86933 |
1238 |
AMELY |
1.331 |
1.265 |
0.95 |
0.79442 |
| 46 |
5201 |
extracellular matrix structural
constituent |
H014507_01 |
P3ECSL |
NM_022164 |
173508 |
LIECG3 |
0.929 |
0.847 |
0.91 |
0.51546 |
| 47 |
5201 |
extracellular matrix structural
constituent |
H015060_01 |
Smooth muscle cell-expressed and
macrophage conditioned medium-induced protein smag-64 |
NM_020351 |
283100 |
LOC57086 |
0.419 |
0.612 |
1.46 |
0.01543 |
| 48 |
5201 |
extracellular matrix structural
constituent |
H001146_01 |
Opticin |
AJ133790 |
241413 |
OPTC |
2.525 |
5.605 |
2.22 |
0.06954 |
| 49 |
5201 |
extracellular matrix structural
constituent |
H001149_01 |
Microfibrillar-associated
protein 2 |
U19718 |
83551 |
MFAP2 |
3.978 |
6.902 |
1.74 |
0.00148 |
| 50 |
5201 |
extracellular matrix structural
constituent |
H001198_01 |
Homo sapiens, alpha-1 (VI)
collagen |
M20776 |
25459 |
|
7.041 |
6.65 |
0.94 |
0.79953 |
| 51 |
5201 |
extracellular matrix structural
constituent |
H001200_01 |
Microfibril-associated
glycoprotein-2 |
NM_003480 |
300946 |
MAGP2 |
10.634 |
11.229 |
1.06 |
0.87915 |
| 52 |
5201 |
extracellular matrix structural
constituent |
H016066_01 |
Homo sapiens mRNA for MSF-FN70
(FN gene) |
AJ276395 |
321592 |
|
6.836 |
13.007 |
1.90 |
0.07589 |
| 53 |
5201 |
extracellular matrix structural
constituent |
H016249_01 |
Homo sapiens, Similar to
laminin, alpha 4, clone MGC:10389, mRNA, complete cds |
BC004241 |
327703 |
|
1.019 |
0.689 |
0.68 |
0.05838 |
| 54 |
776 |
kinetochore |
H002651_01 |
Presenilin 1 (Alzheimer disease
3) |
L76517 |
3260 |
PSEN1 |
1.674 |
1.337 |
0.80 |
0.38047 |
| 55 |
776 |
kinetochore |
H003796_01 |
Centromere protein F (350/400kD,
mitosin) |
U30872 |
77204 |
CENPF |
0.908 |
1.193 |
1.31 |
0.40243 |
| 56 |
776 |
kinetochore |
H004455_01 |
SMT3 (suppressor of mif two 3,
yeast) homolog 1 |
X99584 |
85119 |
SMT3H1 |
1.312 |
0.851 |
0.65 |
0.03052 |
| 57 |
776 |
kinetochore |
H000555_01 |
MAD2 (mitotic arrest deficient,
yeast, homolog)-like 1 |
U65410 |
79078 |
MAD2L1 |
3.691 |
14.522 |
3.93 |
0.00753 |
| 58 |
776 |
kinetochore |
H007906_01 |
Kinesin-like 4 |
AB017430 |
119324 |
KNSL4 |
0.484 |
0.313 |
0.65 |
0.15055 |
| 59 |
776 |
kinetochore |
H009464_01 |
Centromere protein F (350/400kD,
mitosin) |
NM_016343 |
77204 |
CENPF |
0.806 |
0.968 |
1.20 |
0.10591 |
| 60 |
776 |
kinetochore |
H010859_01 |
BUB3 (budding uninhibited by
benzimidazoles 3, yeast) homolog |
AF047472 |
40323 |
BUB3 |
0.88 |
0.571 |
0.65 |
0.01436 |
| 61 |
776 |
kinetochore |
H014640_01 |
Kinetochore protein CENP-H |
NM_022909 |
200395 |
CENPH |
0.515 |
0.361 |
0.70 |
0.16289 |
| 62 |
776 |
kinetochore |
H001444_01 |
Dynactin 2 (p50) |
U50733 |
84153 |
DCTN2 |
1.693 |
2.254 |
1.33 |
0.05946 |
| 63 |
6401 |
RNA catabolism |
H001873_01 |
Zinc finger protein homologous
to Zfp-36 in mouse |
M92843 |
1665 |
ZFP36 |
1.293 |
1.109 |
0.86 |
0.47715 |
| 64 |
6401 |
RNA catabolism |
H004497_01 |
KIAA0116 protein |
D29958 |
182877 |
KIAA0116 |
0.341 |
0.537 |
1.57 |
0.00154 |
| 65 |
6401 |
RNA catabolism |
H006056_01 |
Regulator of nonsense
transcripts 1 |
D86988 |
12719 |
RENT1 |
1.267 |
1.299 |
1.03 |
0.90558 |
| 66 |
6401 |
RNA catabolism |
H006885_01 |
Ribonuclease 6 precursor |
NM_003730 |
8297 |
RNASE6PL |
0.712 |
0.438 |
0.62 |
0.03907 |
| 67 |
6401 |
RNA catabolism |
H008151_01 |
Heat shock 70kD protein 1B |
NM_005346 |
274402 |
HSPA1B |
1.036 |
0.533 |
0.51 |
0.01103 |
| 68 |
6401 |
RNA catabolism |
H008749_01 |
PRO2047 protein |
NM_014110 |
284136 |
PRO2047 |
0.948 |
1.128 |
1.19 |
0.35127 |
| 69 |
6401 |
RNA catabolism |
H010646_01 |
Ribonuclease 6 precursor |
AK001769 |
8297 |
RNASE6PL |
0.862 |
0.836 |
0.97 |
0.71042 |
| 70 |
6401 |
RNA catabolism |
H010958_01 |
Poly(A)-binding protein,
cytoplasmic 4 (inducible form) |
U75686 |
169900 |
PABPC4 |
1.3 |
0.758 |
0.58 |
0.00593 |
| 71 |
6401 |
RNA catabolism |
H011931_01 |
Protein phosphatase 1,
regulatory (inhibitor) subunit 8 |
U14575 |
78961 |
PPP1R8 |
1.351 |
0.949 |
0.70 |
0.21242 |
| 72 |
5520 |
insulin-like growth factor
binding |
H002800_01 |
Connective tissue growth factor |
X78947 |
75511 |
CTGF |
3.098 |
14.225 |
4.59 |
0.00073 |
| 73 |
5520 |
insulin-like growth factor
binding |
H003420_01 |
Insulin-like growth factor
binding protein 6 |
M62402 |
274313 |
IGFBP6 |
2.297 |
1.431 |
0.62 |
0.06015 |
| 74 |
5520 |
insulin-like growth factor
binding |
H003735_01 |
Insulin-like growth factor
binding protein 5 |
AF055033 |
107169 |
IGFBP5 |
1.33 |
1.69 |
1.27 |
0.46462 |
| 75 |
5520 |
insulin-like growth factor
binding |
H003777_01 |
Insulin-like growth factor
binding protein 2 (36kD) |
X16302 |
162 |
IGFBP2 |
0.195 |
0.401 |
2.06 |
0.09799 |
| 76 |
5520 |
insulin-like growth factor
binding |
H000589_01 |
Cysteine-rich, angiogenic
inducer, 61 |
Y11307 |
8867 |
CYR61 |
5.224 |
7.438 |
1.42 |
0.31927 |
| 77 |
5520 |
insulin-like growth factor
binding |
H007289_01 |
Insulin-like growth factor
binding protein 7 |
S75725 |
119206 |
IGFBP7 |
1.036 |
1.769 |
1.71 |
0.20545 |
| 78 |
5520 |
insulin-like growth factor
binding |
H012536_01 |
Human insulin-like growth factor
binding protein 5 (IGFBP5) mRNA |
L27560 |
103391 |
|
0.841 |
1.699 |
2.02 |
0.02933 |
| 79 |
4252 |
serine-type endopeptidase
activity |
H001768_01 |
Protease, serine, 2 (trypsin 2) |
M27602 |
241561 |
PRSS2 |
0.224 |
0.131 |
0.58 |
0.23624 |
| 80 |
4252 |
serine-type endopeptidase
activity |
H001780_01 |
Protease, serine, 4 (trypsin 4,
brain) |
X72781 |
58247 |
PRSS4 |
0.566 |
0.794 |
1.40 |
0.28828 |
| 81 |
4252 |
serine-type endopeptidase
activity |
H001785_01 |
Hepsin (transmembrane protease,
serine 1) |
X07732 |
823 |
HPN |
0.834 |
1.882 |
2.26 |
0.01749 |
| 82 |
4252 |
serine-type endopeptidase
activity |
H001797_01 |
Protease, serine, 1 (trypsin 1) |
M22612 |
241395 |
PRSS1 |
2.029 |
2.174 |
1.07 |
0.5579 |
| 83 |
4252 |
serine-type endopeptidase
activity |
H001828_01 |
Pancreatic elastase IIB |
M16653 |
169234 |
LOC51032 |
1.085 |
1.765 |
1.63 |
0.12304 |
| 84 |
4252 |
serine-type endopeptidase
activity |
H001830_01 |
Transmembrane protease, serine 2 |
U75329 |
318545 |
TMPRSS2 |
1.334 |
1.114 |
0.84 |
0.54555 |
| 85 |
4252 |
serine-type endopeptidase
activity |
H001920_01 |
Coagulation factor VII (serum
prothrombin conversion accelerator) |
M13232 |
36989 |
F7 |
0.98 |
1.638 |
1.67 |
0.05764 |
| 86 |
4252 |
serine-type endopeptidase
activity |
H001925_01 |
Granzyme M (lymphocyte met-ase
1) |
NM_005317 |
268531 |
GZMM |
0.644 |
1.061 |
1.65 |
0.03318 |
| 87 |
4252 |
serine-type endopeptidase
activity |
H002030_01 |
Tryptase, alpha |
M30038 |
278528 |
TPS1 |
1.225 |
0.924 |
0.75 |
0.07983 |
| 88 |
4252 |
serine-type endopeptidase
activity |
H002188_01 |
Lipoprotein, Lp(a) |
X06290 |
119520 |
LPA |
0.655 |
1.066 |
1.63 |
0.06567 |
| 89 |
4252 |
serine-type endopeptidase
activity |
H002460_01 |
Plasminogen activator, tissue |
M15518 |
274404 |
PLAT |
0.852 |
0.76 |
0.89 |
0.58882 |
| 90 |
4252 |
serine-type endopeptidase
activity |
H002509_01 |
D component of complement
(adipsin) |
M84526 |
155597 |
DF |
1.468 |
0.957 |
0.65 |
0.02192 |
| 91 |
4252 |
serine-type endopeptidase
activity |
H002528_01 |
Granzyme K (serine protease,
granzyme 3; tryptase II) |
U26174 |
3066 |
GZMK |
0.919 |
1.163 |
1.27 |
0.33764 |
| 92 |
4252 |
serine-type endopeptidase
activity |
H002553_01 |
Serine (or cysteine) proteinase
inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), |
M14083 |
82085 |
SERPINE1 |
0.841 |
1.12 |
1.33 |
0.01068 |
| 93 |
4252 |
serine-type endopeptidase
activity |
H002605_01 |
Mannan-binding lectin serine
protease 2 |
X98400 |
119983 |
MASP2 |
0.608 |
0.51 |
0.84 |
0.42079 |
| 94 |
4252 |
serine-type endopeptidase
activity |
H002927_01 |
Serine (or cysteine) proteinase
inhibitor, clade B (ovalbumin), member 2 |
Y00630 |
75716 |
SERPINB2 |
0.558 |
0.682 |
1.22 |
0.60481 |
| 95 |
4252 |
serine-type endopeptidase
activity |
H003011_01 |
Complement component 1, s
subcomponent |
J04080 |
169756 |
C1S |
16.305 |
18.098 |
1.11 |
0.78389 |
| 96 |
4252 |
serine-type endopeptidase
activity |
H003053_01 |
Kallikrein 11 |
AB012917 |
57771 |
KLK11 |
0.416 |
0.554 |
1.33 |
0.27282 |
| 97 |
4252 |
serine-type endopeptidase
activity |
H003287_01 |
Kallikrein 5 |
NM_012427 |
50915 |
KLK5 |
1.005 |
1.643 |
1.63 |
0.08562 |
| 98 |
4252 |
serine-type endopeptidase
activity |
H003337_01 |
B-factor, properdin |
L15702 |
69771 |
BF |
0.614 |
0.963 |
1.57 |
0.11883 |
| 99 |
4252 |
serine-type endopeptidase
activity |
H003368_01 |
Kallikrein 1,
renal/pancreas/salivary |
M25629 |
123107 |
KLK1 |
0.86 |
0.863 |
1.00 |
0.9892 |
| 100 |
4252 |
serine-type endopeptidase
activity |
H003754_01 |
ClpP (caseinolytic protease,
ATP-dependent, proteolytic subunit, E. coli) homolog |
Z50853 |
74362 |
CLPP |
1.219 |
0.922 |
0.76 |
0.0866 |
| 101 |
4252 |
serine-type endopeptidase
activity |
H003865_01 |
Lactotransferrin |
X53961 |
105938 |
LTF |
0.65 |
0.466 |
0.72 |
0.17982 |
| 102 |
4252 |
serine-type endopeptidase
activity |
H003877_01 |
Paired basic amino acid cleaving
enzyme (furin, membrane associated receptor protein) |
X17094 |
59242 |
PACE |
1.199 |
0.917 |
0.76 |
0.21199 |
| 103 |
4252 |
serine-type endopeptidase
activity |
H004648_01 |
Tryptase gamma 1 |
NM_012467 |
278275 |
TPSG1 |
0.816 |
1.161 |
1.42 |
0.06632 |
| 104 |
4252 |
serine-type endopeptidase
activity |
H000491_01 |
Proprotein convertase
subtilisin/kexin type 7 |
U33849 |
32978 |
PCSK7 |
1.697 |
1.141 |
0.67 |
0.01513 |
| 105 |
4252 |
serine-type endopeptidase
activity |
H005647_01 |
Membrane-bound transcription
factor protease, site 1 |
D42053 |
75890 |
MBTPS1 |
1.72 |
2.046 |
1.19 |
0.61228 |
| 106 |
4252 |
serine-type endopeptidase
activity |
H006381_01 |
Protease, serine, 23 |
AF015287 |
325820 |
SPUVE |
1.423 |
2.047 |
1.44 |
0.18652 |
| 107 |
4252 |
serine-type endopeptidase
activity |
H007042_01 |
Complement C1r-like proteinase
precursor, |
AF178985 |
98571 |
LOC51279 |
1.077 |
0.984 |
0.91 |
0.48438 |
| 108 |
4252 |
serine-type endopeptidase
activity |
H013087_01 |
Rhomboid (veinlet,
Drosophila)-like |
Y17108 |
137572 |
RHBDL |
0.891 |
0.853 |
0.96 |
0.86092 |
| 109 |
4252 |
serine-type endopeptidase
activity |
H015697_01 |
Transmembrane protease, serine 3 |
NM_024022 |
298241 |
TMPRSS3 |
0.984 |
0.702 |
0.71 |
0.11262 |
| 110 |
4252 |
serine-type endopeptidase
activity |
H001308_01 |
Proteinase 3 (serine proteinase,
neutrophil, Wegener granulomatosis autoantigen) |
X55668 |
928 |
PRTN3 |
0.819 |
1.211 |
1.48 |
0.216 |
| 111 |
4252 |
serine-type endopeptidase
activity |
H001448_01 |
HtrA-like serine protease |
NM_013247 |
115721 |
OMI |
1.18 |
1.41 |
1.19 |
0.18541 |
| 112 |
8287 |
protein serine/threonine
phosphatase complex |
H002974_01 |
KIAA0015 gene product |
D13640 |
278441 |
KIAA0015 |
1.756 |
1.368 |
0.78 |
0.23236 |
| 113 |
8287 |
protein serine/threonine
phosphatase complex |
H003020_01 |
Protein phosphatase 1A (formerly
2C), magnesium-dependent, alpha isoform |
S87759 |
57764 |
PPM1A |
2.483 |
4.223 |
1.70 |
0.1493 |
| 114 |
8287 |
protein serine/threonine
phosphatase complex |
H003074_01 |
Protein phosphatase 2 (formerly
2A), regulatory subunit B (PR 52), alpha isoform |
M64929 |
179574 |
PPP2R2A |
0.9 |
0.594 |
0.66 |
0.17157 |
| 115 |
8287 |
protein serine/threonine
phosphatase complex |
H003642_01 |
Protein phosphatase 1G (formerly
2C), magnesium-dependent, gamma isoform |
Y13936 |
17883 |
PPM1G |
0.759 |
0.902 |
1.19 |
0.29144 |
| 116 |
8287 |
protein serine/threonine
phosphatase complex |
H000413_01 |
Protein phosphatase 2,
regulatory subunit B (B56), epsilon isoform |
L76703 |
173328 |
PPP2R5E |
1.03 |
0.825 |
0.80 |
0.24141 |
| 117 |
8287 |
protein serine/threonine
phosphatase complex |
H000464_01 |
Protein phosphatase 2 (formerly
2A), regulatory subunit A (PR 65), beta isoform |
M65254 |
108705 |
PPP2R1B |
1.156 |
1.334 |
1.15 |
0.47031 |
| 118 |
8287 |
protein serine/threonine
phosphatase complex |
H005412_01 |
Protein phosphatase 2,
regulatory subunit B (B56), delta isoform |
L76702 |
118244 |
PPP2R5D |
1.372 |
1.085 |
0.79 |
0.21517 |
| 119 |
8287 |
protein serine/threonine
phosphatase complex |
H006260_01 |
Protein phosphatase 2A 48 kDa
regulatory subunit |
NM_013239 |
124942 |
PR48 |
0.8 |
0.978 |
1.22 |
0.40781 |
| 120 |
8287 |
protein serine/threonine
phosphatase complex |
H000599_01 |
Protein phosphatase 1D
magnesium-dependent, delta isoform |
U78305 |
100980 |
PPM1D |
1.16 |
0.724 |
0.62 |
0.15614 |
| 121 |
8287 |
protein serine/threonine
phosphatase complex |
H000617_01 |
Protein phosphatase 2,
regulatory subunit B (B56), beta isoform |
L42374 |
75199 |
PPP2R5B |
1.334 |
2.159 |
1.62 |
0.15054 |
| 122 |
8287 |
protein serine/threonine
phosphatase complex |
H000644_01 |
Protein phosphatase 2,
regulatory subunit B (B56), alpha isoform |
L42373 |
155079 |
PPP2R5A |
0.581 |
0.802 |
1.38 |
0.12309 |
| 123 |
8287 |
protein serine/threonine
phosphatase complex |
H008583_01 |
Homo sapiens mRNA; cDNA
DKFZp761E0711 (from clone DKFZp761E0711) |
AL157449 |
110095 |
|
1.677 |
1.242 |
0.74 |
0.1797 |
| 124 |
8287 |
protein serine/threonine
phosphatase complex |
H010455_01 |
KIAA1348 protein |
AB037769 |
232696 |
KIAA1348 |
1.084 |
0.986 |
0.91 |
0.23445 |
| 125 |
8287 |
protein serine/threonine
phosphatase complex |
H014726_01 |
Pyruvate dehydrogenase
phosphatase |
NM_018444 |
22265 |
PDP |
1.946 |
1.113 |
0.57 |
0.00658 |
| 126 |
8287 |
protein serine/threonine
phosphatase complex |
H001703_01 |
Protein phosphatase 2 (formerly
2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), bet |
L07590 |
28219 |
PPP2R3 |
1.489 |
1.204 |
0.81 |
0.40966 |
| 127 |
8287 |
protein serine/threonine
phosphatase complex |
H001704_01 |
Protein phosphatase 2,
regulatory subunit B (B56), gamma isoform |
U37352 |
171734 |
PPP2R5C |
1.056 |
1.61 |
1.52 |
0.01011 |
| 128 |
4295 |
trypsin activity |
H001768_01 |
Protease, serine, 2 (trypsin 2) |
M27602 |
241561 |
PRSS2 |
0.224 |
0.131 |
0.58 |
0.23624 |
| 129 |
4295 |
trypsin activity |
H001780_01 |
Protease, serine, 4 (trypsin 4,
brain) |
X72781 |
58247 |
PRSS4 |
0.566 |
0.794 |
1.40 |
0.28828 |
| 130 |
4295 |
trypsin activity |
H001785_01 |
Hepsin (transmembrane protease,
serine 1) |
X07732 |
823 |
HPN |
0.834 |
1.882 |
2.26 |
0.01749 |
| 131 |
4295 |
trypsin activity |
H001797_01 |
Protease, serine, 1 (trypsin 1) |
M22612 |
241395 |
PRSS1 |
2.029 |
2.174 |
1.07 |
0.5579 |
| 132 |
4295 |
trypsin activity |
H001828_01 |
Pancreatic elastase IIB |
M16653 |
169234 |
LOC51032 |
1.085 |
1.765 |
1.63 |
0.12304 |
| 133 |
4295 |
trypsin activity |
H001830_01 |
Transmembrane protease, serine 2 |
U75329 |
318545 |
TMPRSS2 |
1.334 |
1.114 |
0.84 |
0.54555 |
| 134 |
4295 |
trypsin activity |
H001920_01 |
Coagulation factor VII (serum
prothrombin conversion accelerator) |
M13232 |
36989 |
F7 |
0.98 |
1.638 |
1.67 |
0.05764 |
| 135 |
4295 |
trypsin activity |
H001925_01 |
Granzyme M (lymphocyte met-ase
1) |
NM_005317 |
268531 |
GZMM |
0.644 |
1.061 |
1.65 |
0.03318 |
| 136 |
4295 |
trypsin activity |
H002030_01 |
Tryptase, alpha |
M30038 |
278528 |
TPS1 |
1.225 |
0.924 |
0.75 |
0.07983 |
| 137 |
4295 |
trypsin activity |
H002188_01 |
Lipoprotein, Lp(a) |
X06290 |
119520 |
LPA |
0.655 |
1.066 |
1.63 |
0.06567 |
| 138 |
4295 |
trypsin activity |
H002460_01 |
Plasminogen activator, tissue |
M15518 |
274404 |
PLAT |
0.852 |
0.76 |
0.89 |
0.58882 |
| 139 |
4295 |
trypsin activity |
H002509_01 |
D component of complement
(adipsin) |
M84526 |
155597 |
DF |
1.468 |
0.957 |
0.65 |
0.02192 |
| 140 |
4295 |
trypsin activity |
H002528_01 |
Granzyme K (serine protease,
granzyme 3; tryptase II) |
U26174 |
3066 |
GZMK |
0.919 |
1.163 |
1.27 |
0.33764 |
| 141 |
4295 |
trypsin activity |
H002605_01 |
Mannan-binding lectin serine
protease 2 |
X98400 |
119983 |
MASP2 |
0.608 |
0.51 |
0.84 |
0.42079 |
| 142 |
4295 |
trypsin activity |
H003011_01 |
Complement component 1, s
subcomponent |
J04080 |
169756 |
C1S |
16.305 |
18.098 |
1.11 |
0.78389 |
| 143 |
4295 |
trypsin activity |
H003053_01 |
Kallikrein 11 |
AB012917 |
57771 |
KLK11 |
0.416 |
0.554 |
1.33 |
0.27282 |
| 144 |
4295 |
trypsin activity |
H003287_01 |
Kallikrein 5 |
NM_012427 |
50915 |
KLK5 |
1.005 |
1.643 |
1.63 |
0.08562 |
| 145 |
4295 |
trypsin activity |
H003337_01 |
B-factor, properdin |
L15702 |
69771 |
BF |
0.614 |
0.963 |
1.57 |
0.11883 |
| 146 |
4295 |
trypsin activity |
H003368_01 |
Kallikrein 1,
renal/pancreas/salivary |
M25629 |
123107 |
KLK1 |
0.86 |
0.863 |
1.00 |
0.9892 |
| 147 |
4295 |
trypsin activity |
H004648_01 |
Tryptase gamma 1 |
NM_012467 |
278275 |
TPSG1 |
0.816 |
1.161 |
1.42 |
0.06632 |
| 148 |
4295 |
trypsin activity |
H006381_01 |
Protease, serine, 23 |
AF015287 |
325820 |
SPUVE |
1.423 |
2.047 |
1.44 |
0.18652 |
| 149 |
4295 |
trypsin activity |
H007042_01 |
Complement C1r-like proteinase
precursor, |
AF178985 |
98571 |
LOC51279 |
1.077 |
0.984 |
0.91 |
0.48438 |
| 150 |
4295 |
trypsin activity |
H015697_01 |
Transmembrane protease, serine 3 |
NM_024022 |
298241 |
TMPRSS3 |
0.984 |
0.702 |
0.71 |
0.11262 |
| 151 |
4295 |
trypsin activity |
H001308_01 |
Proteinase 3 (serine proteinase,
neutrophil, Wegener granulomatosis autoantigen) |
X55668 |
928 |
PRTN3 |
0.819 |
1.211 |
1.48 |
0.216 |
| 152 |
4295 |
trypsin activity |
H001448_01 |
HtrA-like serine protease |
NM_013247 |
115721 |
OMI |
1.18 |
1.41 |
1.19 |
0.18541 |
| 153 |
43087 |
regulation of GTPase activity |
H004224_01 |
Hypothetical protein FLJ10767 |
AK001629 |
25584 |
FLJ10767 |
1.675 |
1.3 |
0.78 |
0.04097 |
| 154 |
43087 |
regulation of GTPase activity |
H004509_01 |
KIAA0782 protein |
AB018325 |
21264 |
KIAA0782 |
1.008 |
0.783 |
0.78 |
0.1811 |
| 155 |
43087 |
regulation of GTPase activity |
H008446_01 |
KIAA0167 gene product |
D79989 |
184884 |
KIAA0167 |
0.828 |
0.72 |
0.87 |
0.28232 |
| 156 |
43087 |
regulation of GTPase activity |
H009484_01 |
G protein-coupled receptor
kinase-interactor 1 |
NM_014030 |
318339 |
GIT1 |
0.932 |
1.279 |
1.37 |
0.16443 |
| 157 |
43087 |
regulation of GTPase activity |
H001587_01 |
GDP dissociation inhibitor 1 |
X79353 |
74576 |
GDI1 |
1.606 |
1.015 |
0.63 |
0.03322 |
| 158 |
43087 |
regulation of GTPase activity |
H001635_01 |
GDP dissociation inhibitor 2 |
Y13286 |
56845 |
GDI2 |
1.474 |
1.137 |
0.77 |
0.12277 |
| 159 |
6687 |
glycosphingolipid metabolism |
H003235_01 |
GM2 ganglioside activator
protein |
X62078 |
69743 |
GM2A |
1.515 |
1.201 |
0.79 |
0.31178 |
| 160 |
6687 |
glycosphingolipid metabolism |
H004193_01 |
Sialyltransferase 9
(CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) |
AB018356 |
225939 |
SIAT9 |
1.124 |
0.714 |
0.64 |
0.07436 |
| 161 |
6687 |
glycosphingolipid metabolism |
H006323_01 |
CMP-NeuAC:(beta)-N-acetylgalactosaminide
(alpha)2,6-sialyltransferase member VI |
AB035173 |
109672 |
VI |
3.293 |
2.391 |
0.73 |
0.27588 |
| 162 |
6687 |
glycosphingolipid metabolism |
H000076_01 |
UDP-glucose ceramide
glucosyltransferase |
D50840 |
152601 |
UGCG |
1.149 |
1.557 |
1.36 |
0.27117 |
| 163 |
6687 |
glycosphingolipid metabolism |
H000887_01 |
Prosaposin (variant Gaucher
disease and variant metachromatic leukodystrophy) |
J03077 |
78575 |
PSAP |
5.938 |
4.713 |
0.79 |
0.08217 |
| 164 |
6687 |
glycosphingolipid metabolism |
H001450_01 |
Globotriaosylceramide/CD77
synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl |
NM_017436 |
105956 |
A14GALT |
3.059 |
2.119 |
0.69 |
0.26431 |
| 165 |
30148 |
sphingolipid biosynthesis |
H004193_01 |
Sialyltransferase 9
(CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) |
AB018356 |
225939 |
SIAT9 |
1.124 |
0.714 |
0.64 |
0.07436 |
| 166 |
30148 |
sphingolipid biosynthesis |
H006323_01 |
CMP-NeuAC:(beta)-N-acetylgalactosaminide
(alpha)2,6-sialyltransferase member VI |
AB035173 |
109672 |
VI |
3.293 |
2.391 |
0.73 |
0.27588 |
| 167 |
30148 |
sphingolipid biosynthesis |
H000076_01 |
UDP-glucose ceramide
glucosyltransferase |
D50840 |
152601 |
UGCG |
1.149 |
1.557 |
1.36 |
0.27117 |
| 168 |
30148 |
sphingolipid biosynthesis |
H015734_01 |
Sphingosine kinase type 2
isoform |
AL136701 |
301305 |
SPHK2 |
1.457 |
0.927 |
0.64 |
0.1341 |
| 169 |
30148 |
sphingolipid biosynthesis |
H001450_01 |
Globotriaosylceramide/CD77
synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl |
NM_017436 |
105956 |
A14GALT |
3.059 |
2.119 |
0.69 |
0.26431 |
| 170 |
6664 |
glycolipid metabolism |
H003235_01 |
GM2 ganglioside activator
protein |
X62078 |
69743 |
GM2A |
1.515 |
1.201 |
0.79 |
0.31178 |
| 171 |
6664 |
glycolipid metabolism |
H004193_01 |
Sialyltransferase 9
(CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) |
AB018356 |
225939 |
SIAT9 |
1.124 |
0.714 |
0.64 |
0.07436 |
| 172 |
6664 |
glycolipid metabolism |
H006323_01 |
CMP-NeuAC:(beta)-N-acetylgalactosaminide
(alpha)2,6-sialyltransferase member VI |
AB035173 |
109672 |
VI |
3.293 |
2.391 |
0.73 |
0.27588 |
| 173 |
6664 |
glycolipid metabolism |
H006408_01 |
Alpha2,3-sialyltransferase |
AK001922 |
34578 |
ST3GALVI |
0.717 |
0.581 |
0.81 |
0.33202 |
| 174 |
6664 |
glycolipid metabolism |
H000076_01 |
UDP-glucose ceramide
glucosyltransferase |
D50840 |
152601 |
UGCG |
1.149 |
1.557 |
1.36 |
0.27117 |
| 175 |
6664 |
glycolipid metabolism |
H000887_01 |
Prosaposin (variant Gaucher
disease and variant metachromatic leukodystrophy) |
J03077 |
78575 |
PSAP |
5.938 |
4.713 |
0.79 |
0.08217 |
| 176 |
6664 |
glycolipid metabolism |
H001148_01 |
Galactosylceramidase (Krabbe
disease) |
NM_000153 |
273 |
GALC |
1.388 |
1.872 |
1.35 |
0.2603 |
| 177 |
6664 |
glycolipid metabolism |
H001450_01 |
Globotriaosylceramide/CD77
synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl |
NM_017436 |
105956 |
A14GALT |
3.059 |
2.119 |
0.69 |
0.26431 |
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