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Selected pre-clinical research publications

Frederick R. Strebel, Manisha Singh, R. Wanda Rowe, Dorothy E. Lewis, Joan M.C. Bull.
Prediction of outcome after anti-cancer immune stimulation by thermochemotherapy in a rat breast cancer model.
Proc Amer Assoc Cancer Res 49: (Abstract 2089, 99th Annual Meeting), 2008.

Bull JMC, Strebel FR, Jenkins, GN, Deng W, Rowe RW,
The Importance of Schedule in Whole-Body Thermochemotherapy International Journal of Hyperthermia, 2008 Mar;24(2):171-81.

Strebel FR, ZH Siddik, W Deng, Rowe RW, Bull JMC
Long-duration, Fever-range, Thermal Therapy Increases Oxaliplatin-induced Cell Kill, Cellular Platinum Uptake, and Formation of Platinum-DNA Adducts in Breast Cancer Cells Society for Thermal Medicine 2007 Annual Meeting, Washington DC, May 14-17, 2007.

Strebel FR, Proett JM, Rowe RW, Deng W, Bull JMC
Fever-Range Whole Body Thermal Therapy Enhancement of Oxaliplatin Efficacy In Vivo is Schedule Dependent. Proceedings of the Society for Thermal Medicine 2006 Annual Meeting, Bethesda , Maryland , April 5-8, 2006.

Strebel FR, Proett JM, Rowe RW, Deng W, Bull JMC
Effect of oxaliplatin combined with fever-range whole-body thermal-therapy in a rat mammary adenocarcinoma in vivo.
Proc Amer Assoc Cancer Res 47: (Abstract 3847), 2006.

Rowe RW
Hyperthermia, systemic.
In: Encyclopedia of Medical Devices and Instrumentation, ed. John G. Webster, 2nd edition, Wiley Interscience 2006.

Proett JM, Strebel FR, Rowe RW, Deng W, Bull JM. In vivo Effects of Oxaliplatin Combined with Fever-Range Whole-Body
Thermal-Therapy in a Rat Mammary Adenocarcinoma. Proc. Texas Academy of Internal Medicine 2005 Annual Meeting, The Woodlands, TX, November 4-5, 2005.

Strebel FR, Deng W, Rachal E, Loose DS, Alcorn JL, Gopalan B, Ramesh R, Rowe RW, Bull JMC.
Transgene expression in vivo: effects of species difference and intravenous infusion rate of cationic liposome DNA complex.
Proc Amer Assoc Cancer Res 46: [Abstract 3341], 2005.

Rowe RW, Tomoda M, Strebel FR, Jenkins GN, Stephens LC, Bull JM
The natural progression of microvasculature in primary tumor and lymph node metastases in a breast carcinoma model: relationship between microvessel density, vascular endothelial growth factor expression, and metastatic invasion.
Cancer Biol Ther. 2004 Apr;3(4):408-14. Epub 2004 Apr 22.

Strebel FR, Rowe RW, Deng W, Lee AS, Templeton NS, Loose DS, Alcorn JL, Bull JMC
Systemic Transfection of a Rat Mammary Adenocarcinoma using a Glucose-Regulated Protein Promoter-Driven Reporter Gene Complexed to a Novel Cationic Liposome.
Proc. 9th International Congress on Hyperthermic Oncology, St. Louis, MO, April 20-24, 2004 (abstract).

Strebel FR, Deng W, Loose DS, Huanzhang Lu, Templeton NS, Lee AS, Alcorn JL, Rowe RW, Bull JMC
Hyperthermia Enhances Systemic Gene Delivery and Expression in Tumors.
Proc Amer Assoc Cancer Res 45, 2004 (abstract).

Rowe RW, Strebel FR, Sumiyoshi K, Kirpotin DB, Bull JMC
Tumor tissue and necrotic fluid weight and distribution as a function of tumor growth.
Proc Amer Asso Cancer Res 44 (2 nd ed.): R348, 2003 (abstract).

Strebel FR, Harris TJ, Olson LE, Lee AS, Templeton NS, Loose DS, Rowe RW, Bull JMC
Selective systemic transfection of a rat mammary adenocarcinoma using a glucose-regulated protein promoter-driven reporter gene complexed to a novel cationic liposome.
Proc Amer Asso Cancer Res 44 (2 nd ed.): R6495, 2003 (abstract).

Sumiyoshi K, Strebel FR, Rowe RW, Bul JMC
The effect of whole body hyperthermia combined with metronomic chemotherapy on rat mammary adenocarcinoma metastases.
Intl J Hyperthermia, 2003 Mar-Apr; 19(2): 103-18.

Rowe RW, Strebel FR, Sumiyoshi K, Kirpotin DB, Bull JMC
Time course of liposome uptake in MTLN3 tumors and normal tissue with and without whole body hyperthermia.
Proc Amer Asso Cancer Res 43:417, 2002 (abstract).

Strebel FR, Sumiyoshi K, Jenkins GN, Rowe RW, Bull JMC
Drug sequence effect on therapeutic outcome (tumor growth, toxicity, and survival) of Irinotecan combined with Epirubicin in the in vivo MTLn3 rat mammary adenocarcinoma.
Proc Amer Asso Cancer Res 43:587, 2002 (abstract).

Sumiyoshi K, Strebel FR, Rowe-Horwege RW, Bull JMC
The Effect of Whole-Body Hyperthermia and a low-dose Topoisomerase I inhibitor (CPT-11) on Occult Metastases in a Rat Breast Cancer Model.
Proc Amer Asso Cancer Res 43:247 2002 (abstract).

Rowe RW, Kirpotin DB, Strebel FR, Jenkins GN, Hong K, Bull JMC
Uptake of 67Ga-labeled sterically stabilized liposomes in rat MTLN3 primary tumors following whole body hyperthermia (WBH).
Proc Amer Asso Cancer Res 41:423, 2000 (abstract).

Sumiyoshi K, Liles N, Strebel FR, Horwege RW, Jenkins GN, Bull JMC
The Effect of Bolus Combined with Metronomic Administration of Camptosar (CPT-11) in Mammary Carcinoma Lymph Node Metastases in Rat
Proc Amer Asso Cancer Res 42:101, 2001 (abstract).

Tomoda M, Strebel FR, Jenkins GN, Rowe RW, Stephens LC, Bull MC
Comparison of microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression between primary tumor and lymph node metastasis in the MTLN3 rat mammary adenocarcinoma.
Proc Amer Asso Cancer Res 41:168 (abstract 1074), 2000.

Bull JMC, Strebel FR, Jenkins GN, Tomoda M, Rowe RW
Sequence dependency of antitumor effect of gemcitabine combined with cisplatin in the highly metastatic MTLN3 rat mammary adenocarcinoma.
Proc Amer Asso Cancer Res 41:410 (abstract 2609), 2000.

Toyota N, Strebel FR, Stephens LC, Rowe W, Matsuda H, Oshiro T, Jenkins GN, Bull JM
Effect of altered duration of 41.5 degrees C whole body hyperthermia in combination with cis-diamminedichloroplatinum (II) on tumor and normal tissue apoptosis and tumor response in rats.
Oncol Rep. 1998 Sep-Oct;5(5):1231-6.

Tomoda M, Strebel FR, Jenkins GN, Rowe W, Stephens LC, Bull JM
Microvasculature in the natural progression of lymph node metastasis in a rat breast cancer model: Relationship between vascular endothelial growth factor (VEGF) expression, microvessel density, and histopathological findings.
Proc Amer Asso Cancer Res 40:456 (abstract 3013), 1999.

Rowe RW, Toyota N, Strebel F, Stephens LC, Jenkins GN, Matsuda H, Bull JMC
Relationship between apoptosis, necrosis, and antitumor effect in a breast cancer model after treatment with cisplatin (CDDP), doxorubicin (DOX) and who body hyperthermia (WBH).
Proc Amer Asso Cancer Res 40:481 (abstract 3177), 1999.

Bull JMC, Loo CH, Strebel FR, Jenkins GN, Tomoda M, Rowe RW.
Treatment of a highly metastatic mammary adenocarcinoma with fever-range, long-duration, low-temperature (40°C for 6 h) whole body hyperthermia (LL-WBH) combined with gemcitabine (dFdC) in rats.
Proc Amer Asso Cancer Res 40:552 (abstract 3643), 1999.

Toyota N, Strebel FR, Stephens LC, Matsuda H, Oshiro T, Jenkins GN, Bull JM
Therapeutic efficacy and apoptosis and necrosis kinetics of doxorubicin compared with cisplatin, combined with whole-body hyperthermia in a rat mammary adenocarcinoma.
Int J Cancer. 1998 May 18;76(4):499-505.

Oshiro T, Jenkins GN, Rowe RW, Strebel FR, Matsuda H, Nagle V, Bull JMC
Whole body hyperthermia (WBH) induces vascular endothelial cell growth factor (VEGF) followed by decreased microvascular density in solid tumor.
Proc Amer Assoc Cancer Res, New Orleans , LA , 1998 (abstract).

Toyota N, Strebel FR, Stephens LC, Matsuda H, Bull JM
Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis in a metastatic rat mammary adenocarcinoma.
Int J Hyperthermia. 1997 Sep-Oct;13(5):497-506.

Kaneko T, Sakaguchi Y, Makino M, Matsuda H, Strebel FR, Jenkins GN, Bull JM
Optimal duration of whole body hyperthermia when combined with cis-diaminne-1,1-cychlobutane dicarboxylate platinum (II) (carboplatin).
Anticancer Res. 1997 May-Jun;17(3C):1897-901.

Matsuda H, Strebel FR, Kaneko T, Danhauser LL, Jenkins GN, Toyota N, Bull JM
Long duration-mild whole body hyperthermia of up to 12 hours in rats: feasibility, and efficacy on primary tumour and axillary lymph node metastases of a mammary adenocarcinoma: implications for adjuvant therapy.
Int J Hyperthermia. 1997 Jan-Feb;13(1):89-98.

Makino M, Lodato RF, Stephens LC, Strebel FR, Jenkins G, Ohno S, Sakaguchi Y, Kostergaard J, Tomasovic SP, Bull JM
Protective effect of NG-monomethyl-L-arginine against hypotension inducted by combined tumour necrosis factor-alpha and whole body hyperthermia in rats.
Int J Hyperthermia. 1996 Sep-Oct;12(5):617-34.

Matsuda H, Strebel FR, Kaneko T, Stephens LC, Danhauser LL, Jenkins GN, Toyota N, Bull JM
Apoptosis and necrosis occurring during different stages of primary and metastatic tumor growth of a rat mammary adenocarcinoma.
Anticancer Res. 1996 May-Jun;16(3A):1117-21.

Sakaguchi Y, Stephens LC, Makino M, Kaneko T, Strebel FR, Danhauser LL, Jenkins GN, Bull JM
Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats.
Cancer Res. 1995 Nov 15;55(22):5459-64.

Wondergem J, Strebel FR, Stephens LC, Siddik ZH, Bull JM
Chronic effect of whole-body hyperthermia combined simultaneously with cis-diamminedichloroplatinum (II) on normal tissue in rat.
Int J Hyperthermia. 1995 Jan-Feb;11(1):37-47.

Sakaguchi Y, Stephens LC, Makino M, Kaneko T, Strebel FR, Danhauser LL, Jenkins GN, Bull JM
Apoptosis in normal tissues induced by 5-fluorouracil: comparison between bolus injection and prolonged infusion.
Anticancer Res. 1994 Jul-Aug;14(4A):1489-92.

Sakaguchi Y, Makino M, Kaneko T, Stephens LC, Strebel FR, Danhauser LL, Jenkins GN, Bull JM
Therapeutic efficacy of long duration-low temperature whole body hyperthermia when combined with tumor necrosis factor and carboplatin in rats.
Cancer Res. 1994 Apr 15;54(8):2223-7.

Ohno S, Siddik ZH, Kido Y, Zwelling LA, Bull JM
Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells.
Cancer Chemother Pharmacol. 1994;34(4):302-6.

Ohno S, Strebel FR, Stephens LC, Siddik ZH, Baba H, Makino M, Khokhar AR, Bull JM
Haematological toxicity of carboplatin and cisplatin combined with whole body hyperthermia in rats.
Br J Cancer. 1993 Sep;68(3):469-74.

Wondergem J, Siddik ZH, Strebel FR, Bull JM
Effect of whole body hyperthermia on cis-diamminedichloroplatinum (II)-induced antitumour activity and tissue Pt-distribution: do anaesthetics influence the therapeutic ratio?
Eur J Cancer. 1993;29A(4):549-54.

Ohno S, Strebel FR, Stephens LC, Siddik ZH, Makino M, Klostergaard J, Tomasovic SP, Khokhar AR, Bull JM
Increased therapeutic efficacy induced by tumor necrosis factor alpha combined with platinum complexes and whole-body hyperthermia in rats.
Cancer Res. 1992 Aug 1;52(15):4096-101.

Newman RA, Dogramatzis D, Benvenuto JA, Trevino M, Stephens LC, Wondergem J, Strebel R, Baba H, Bull JM
Effect of whole-body hyperthermia on pharmacokinetics and tissue distribution of doxorubicin.
Int J Hyperthermia. 1992 Jan-Feb;8(1):79-85.

Wondergem J, Stephens LC, Strebel FR, Baba H, Ohno S, Siddik ZH, Newman RA, Bull JM
Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues.
Cancer Res. 1991 Jul 1;51(13):3559-67.

Baba H, Stephens LC, Strebel FR, Siddik ZH, Newman RA, Ohno S, Bull JM
Protective effect of ICRF-187 against normal tissue injury induced by adriamycin in combination with whole body hyperthermia.
Cancer Res. 1991 Jul 1;51(13):3568-77.

Ohno S, Siddik ZH, Baba H, Stephens LC, Strebel FR, Wondergem J, Khokhar AR, Bull JM
Effect of carboplatin combined with whole body hyperthermia on normal tissue and tumor in rats.
Cancer Res. 1991 Jun 1;51(11):2994-3000.

Baba H, Siddik ZH, Strebel FR, Jenkins GN, Bull JM
Increased therapeutic gain of combined cis-diamminedichloroplatinum (II) and whole body hyperthermia therapy by optimal heat/drug scheduling.
Cancer Res. 1989 Dec 15;49(24 Pt 1):7041-4.

Wondergem J, Bulger RE, Siddik ZH, Leygraaf JW, Strebel FR, Alonso M, Travis EL, Bull JM
A comparison of thermal enhancement of cis-diamminedichloroplatinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat.
Int J Radiat Oncol Biol Phys. 1989 Jun;16(6):1551-6.

Wondergem J, Strebel FR, Siddik ZH, Newman RA, Bull JM
The effects of anaesthetics on cisplatinum-induced toxicity at normal temperatures and during whole-body hyperthermia: the influence of NaCl concentration of the vehicle.
Int J Hyperthermia. 1988 Nov-Dec;4(6):643-54.

Bull JM, Strebel FR, Sunderland BA, Bulger RE, Edwards M, Siddik ZH, Newman RA
o-(beta-Hydroxyethyl)-rutoside-mediated protection of renal injury associated with cis-diamminedichloroplatinum(II)/hyperthermia treatment.
Cancer Res. 1988 Apr 15;48(8):2239-44.

Wondergem J, Bulger RE, Strebel FR, Newman RA, Travis EL, Stephens LC, Bull JM
Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury.
Cancer Res. 1988 Jan 15;48(2):440-6.

Dobyan DC, Bull JM, Strebel FR, Sunderland BA, Bulger RE
Protective effects of O-(beta-hydroxyethyl)-rutoside on cis-platinum-induced acute renal failure in the rat.
Lab Invest. 1986 Nov;55(5):557-63.

Bull JM
An update on the anticancer effects of a combination of chemotherapy and hyperthermia.
Cancer Res. 1984 Oct;44(10 Suppl):4853s-4856s.

Bull JM
A review of systemic hyperthermia.
Front Radiat Ther Oncol. 1984;18:171-6. Review. No abstract available.

Bull JM, Lees DE, Schuette WH, Smith R, Glatstein E, DeVita VT Jr
Immunological and physiological responses to whole-body hyperthermia.
Natl Cancer Inst Monogr. 1982 Jun;61:177-81.




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