The Department of Surgery at the University of Texas Medical School at Houston
Department of Surgery
Division of Urology

Faculty Profile

Jiuhong Yuan , MD

Research Associate
Division of Urology
Department of Surgery


Education:

Ph.D. candidate, Graduate School of Peking Union Medical College (PUMC)
Beijing, China
1997—1999

M.D., West China University of Medical Science
Chengdu, Sichuan Province, China
1983—1989

POSTGRADUATE EXPERIENCE

01/2003—present Postdoctoral Fellow, Department of Internal Medicine, The University of TexasMedical School, Houston, TX.

11/2002—12/2003 Postdoctoral Fellow, Division of Surgery, The University of Texas MD
Anderson Cancer Center, Houston, TX.

12/2000—10/2002 Postdoctoral Fellow, Division of Cancer medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

04/2000—12/2000 Assistant professor, Department of Urology, PUMC Hospital, Beijing, China.

09/1999—03/2000 Visiting scholar, Department of Urology, Queen Marry Hospital, Hong Kong University, Hong Kong.

06/1996—08/1999 Assistant professor, Department of Urology, PUMC Hospital, Beijing, China.

05/1992—05/1996 Fellow in Department of Urology, PUMC Hospital, Beijing, China.

08/1989—04/1992 Resident in Surgery, PUMC Hospital, Beijing, China.

08/1988—07/1989 Intern, PUMC Hospital, Beijing, China.

TECHNICAL EXPERTISE
  • Lab techniques (certified: (1) animal care, (2) the safe handling of radioactive materials in research and clinical laboratories, and (3) safety in the laboratory and clinical environment)
  • Molecular Biology: DNA, RNA and protein isolation, purification and analysis (Southern, Northern, Western blotting, PCR, RT-PCR and Quantitative PCR); gene cloning; genotyping; sequence, pyrosequence; protein-protein or protein-DNA interaction analysis; gene promoter analysis, DNA methylation, ligation and transfection; adenovirus-inducible system and transgenic mice generation
  • Cell Biology: Establishment and maintenance of cell lines including primary culture from normal and malignant human tissues. Cell proliferation and apoptosis assays
  • Pathology: Treatment of fresh tissue, cut slides, H & E stain, microdissection
  • Animal: Management of barrier, biohazard and convention mice, mice surgery
  • Skillful of PC & Mac, especially on Microsoft Office, Canvas, Photoshop, MacVector, Winstat, Chromas, Genescan, Genemapper, Cyrillic and Progeny.

PROFESSIONAL APPOINTMENTS

Assistant Professor, Department of Urology, PUMC Hospital
Beijing, China,
1995—2000

Principal Investigator in phase I & II study of Viagra in China,
1996—2000

AFFILIATIONS AND HONORS

American Association for Cancer Research, 2001-present
Chinese Society of Urology, 1994-present
Chinese Medical Association, 1994-present
Cheng Yu Tung Research Fellowship, Hong Kong University, Queen Mary Hospital (Hong Kong), 1999-2000
Research Excellence Award, PUMC, 1996

SELECTED PUBLICATIONS

  1. 1. Nili Avidan, Yuan JH, Milewicz DM. A Novel Locus for Familial Thoracic Aortic Aneurysms and Dissection Mapped to 15q24-26 (TAAD3): Locus Specific Phenotypes for Familial Aortic Disease. Circulation. In press.
  2. Fadulu VT, Yuan JH, Milewicz DM. Familial Thoracic Aortic Aneurysms and Dissections: Novel Phenotype of Autosomal Dominant Inheritance of Ascending and Descending Aortic Dissections. The American Journal of Medical Genetics. In press.
  3. Yuan JH, Bast RC Jr, Yu YH. et al. Aberrant methylation and Silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancer. Cancer Research, 63: 4174-4180, July 15, 2003.
  4. Fujii S, Yuan JH, Bast RC Jr. et al. Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Human Molecular Genetics, 1791-1800, August 1, 2003.
  5. Wang L., Yuan JH, Yu YH. et al. Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clinic Cancer Research, 3660-3666, September 1, 2003.
  6. Yu YH, Yuan JH, Bast RC Jr. et al. Epigenetic Regulation of ARHI in Breast and Ovarian Cancer Cells. Epigenetics in Cancer Prevention Early Detection and Risk Assessment. The Annals of the New York Academy of Sciences, 983: 268-277, March, 2003.
  7. Yuan JH, Bast RC Jr, Yu YH. et al. Aberrant methylation inhibits expression of the imprinted tumor suppressor gene ARHI in human breast cancer. Proceedings American Association for Cancer Research, 43:1114-1115, 2002.
  8. Fujii S, Yuan JH, Yu YH. et al. Transcriptional reactivation of the imprinted tumor suppressor gene ARHI in human breast cancer by inhibition of histone deacetylase. Proceedings American Association for Cancer Research, 43:1116, 2002.
  9. Bao JJ, Yuan JH, Bast RC Jr. et al. Re-expression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. Cancer Research, 62: 7264-7272, 2001.
  10. Yuan JH, Li YD, Xu FJ. Caruncle excision with CO2 laser under local anesthesia. Chinese Journal of Laser Medicine & Surgery. 13 (3): 111-113, 2001.
  11. Yuan JH, Bao N, Xu FJ. et al. Preoperative diagnosis of benign renal tumor. Chinese Journal of Urology. 5: 274-277, 2000.
  12. Yuan JH, Li YD, Xu FJ. Preoperative diagnosis of benign testicular tumor. Chinese Journal of Urology. 4: 247, 2000.
  13. Yuan JH, Li YD, Xu FJ. Case report of testicular adenoid tumor. Beijing Medical Journal. 2: 69, 2000.
  14. Bao N, Ji ZG, Yuan JH, et al. The diagnosis and treatment of renal carcinoma with tumor thrombus in inferior vena cava (A report of 5 cases). Beijing Medical Journal. 4: 135-137, 1999.
  15. Dai Q, Jiang YX, Yuan JH, et al. The diagnosis value of the ultrasound-contrast agent in renal masses. Chinese Journal of Urology. 20 (4): 199-201, 1999.
  16. Bao N, Yuan JH, Xu FJ, et al. Diagnosis and prognosis of renal carcinoma thrombus in inferior vena cava. Chinese Medicine Journal of Jiangsu 9: 84-86, 1998.
    16. Yuan JH, Sun XJ, Ji ZG, et al. Report of 300 cases with CO2 laser circumcision. Chinese Journal of Laser Medicine & Surgery. 6 (1): 35-37, 1997.
  17. Cao J, Yuan JH and Xia M. 300 questions about infertility. Collaborated Press of Beijing University of Medical Science and P.U.M.C. Beijing, 1997.
  18. Cao J, Yuan JH, Jin W, et al. Clinical trial of an anti-fertility method with testosterone enanthate in normal men. Chinese Medical Journal. 1996, 76 (5): 335-337, 1996.
  19. Liu P, Mao QZ, Yuan JH. Report of 3 cases of benign tumor of epididymis. Journal of Clinical Urology 11 (5): 279, 1996.
  20. Liu P, Xia M, Yuan JH, et al. The in vitro research of collaboration of high-energy shock waves and acetate gossypol on human tumor cell. Chinese Journal of Experimental Surgery 12(4): 241-242, 1995.

SELECTED PRESENTATIONS

  1. 93rd annual meeting of American Association for Cancer Research, San Francisco CA, Apr. 4-10, 2002. “Aberrant methylation inhibits expression of the imprinted tumor suppressor gene ARHI in human breast cancer”.
  2. 6th annual Trainee Recognition Day and Research Exposition of MD Anderson Cancer Center, Houston, TX, May 8-10, 2002 “Methylation is one of the main control factor in the expression of the imprinted tumor suppressor gene ARHI”
  3. 2002 Scientific Symposium of Society of Chinese Bioscientists in America, Houston Texas, Apr. 27, 2002. “Methylation of the imprinted tumor suppressor gene ARHI in human breast cancer”.
  4. 3rd Annual Meeting of Asian Urological Association, Beijing, China, May 6-10, 2000. “Treatment of 1000 cases of urolithiasis”.
  5. 5th Annual Meeting of Chinese Urological Association, Shanghai, China, Sept. 3-10 1998. “Preoperative diagnosis of benign renal tumor”.
  6. 7th Annual meeting of Chinese Laser Medicine Association, Wu Yi Shan, Fu Jian province, China, April 15-20,1995. “Report of 300 cases with CO2 laser circumcision”.
Jiuhong Yuan , MD
Jiuhong Yuan , MD

Research Associate
Division of Urology
Department of Surgery

 
E-mail: Jiuhong.Yuan@uth.tmc.edu
Office Address:
6431 Fannin Street
Suite 6.018
Houston, TX 77030

Office Phone: 713-500-5239
Office Fax: 713-500-0751

For an appointment, call:
832-325-7280