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Clozapine Therapy

Summary

SME: Director of Pharmacy
Last Review Date: 6/11/08


Clozapine is dispensed only to UTHCPC patients that fall within the prescribed UTHCPC medical criteria.

Criteria

A patient must meet the following criteria so s/he can receive Clozapine treatment:

Criterion

Description

1

Patients are eligible for Medicaid to assure possible reimbursement for the cost of the drug.

2

Patients are heavy users of inpatient mental health services, especially during the preceding year.

3

Patients consistently show a lack of acceptable response to at least three different antipsychotic drugs used in adequate doses.

4

Patients have a stable residence and a history of good attendance at clinics.

5

Patients have no contraindications to the use of the drug.

6

Patients have a complete blood count workup performed.

Dispensing approval process

Following is Clozapine dispensing process:

Stage

Description

1

The physician writes an order for Clozaril and a complete blood count (CBC).

2

Does the WBC and the ANC falls within the approved value?

If yes, the pharmacist on duty goes online to register the patient and the physician on Clozapine IVAX webpage to apply for a Rechallenge Clearance Authorization Number.

If the patient does not meet the criteria for clozapine, the Pharmacy informs the physician of the decision from the Clazapine registry.

3

When the Clozapine National Registry accepts the patient for Clozapine treatment, they will fax the eligibility code to the pharmacy.

The Pharmacy department dispenses Clozapine to the patient.

 

Continual

Every UTHCPC patient on Clozapine must have CBC with differential count weekly in order to continue Clozaril therapy. The physician will use the clozapine order set (Dose titration schedule) online to order clozapine.

Clozaril discharged patients

The process of discharging patient on Clozaril is as follows: Pharmacy will dispense three-days worth of medication.

 

Related standard

Related to regulatory standards

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Harris County Psychiatric Center University of Texas Health Science Center