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4	HIF-1stimulates tumor growth High levels of tumor HIF-1a cause aggressive tumor growth and resistance to therapy High levels of tumor HIF-1a are associated with decreased patient survival Experimental studies show that inhibiting HIF-1a with knockout, antisense, shRNA or drugs inhibits tumor growth HIF-1a is a cancer drug target for attacking a vulnerability (Achilles heel) of tumor growth
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10	Effect of PX-478 on HIF-1 transactivation in vivo
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