Rowen J.-Y. Chang, Ph.D.
Professor and Director, Center for Protein Chemistry
phone 713.500.2458;
fax: 713.500.2447
Rowen.Chang@uth.tmc.edu
Dr. Chang obtained his MS degree from the National Taiwan University at Taipei in 1974 and his Ph.D. from the Australian National University at Canberra in 1977. He did his postdoctoral training from 1978 to 1980 at Max-Planck Institute at Berlin (protein chemistry) and Mayo Clinic at Rochester (Immunochemistry).
In 1981, Dr. Chang joined Ciba-Geigy at Basel, Switzerland where he was responsible for the protein chemistry laboratory. In July 1998, he joined the Institute of Molecular Medicine, University of Texas Health Science Center at Houston, as Professor and Director of the Center for Protein Chemistry.
RECENT PUBLICATIONS
Lu, B.-Y., and Chang, J.-Y. (2007) Arch. Biochem. Biophys. 460, 75-84.
A 3-Disulfide Mutant of Mouse Prion Protein: EXPRESSION, OXIDATIVE FOLDING, REDUCTIVE UNFOLDING, CONFORMATIONAL STABILITY, AGGREGATION AND ISOMERIZATION.
Lin, C.-J. and Chang, J.-Y. (2007) Biochemistry 46, 3925-3932.
Pathway of Oxidative Folding of Bovine a-Interferon: PREDOMINANCE OF NATIVE DISULFIDE BONDED FOLDING INTERMEDIATES
Jiang, C., and Chang, J.-Y. (2007) Biochemistry 46, 602-609.
Isomers of Human a-Synuclein Stabilized by Disulfide Bonds Exhibit Distinct Structural and Aggregative Properties.
Zhang, Z., Boyle, P. C., Lu, B.-Y., Chang, J.-Y., and Wriggers, W. (2006) Biochemistry 45, 15269-15278.
Entropic Folding Pathway of Human Epidermal Growth Factor Explored by Disulfide Scrambling and Amplified Collective Motion Simulation.
Lin C.-J., Lu B.-Y., and Chang, J.-Y. (2006) Biochem. Biophys. Acta 1764, 1286-1291.
Conformational Stability of Secretory Leucocyte Protease Inhibitor: A PROTEIN WITH NO HYDROPHOBIC CORE AND VERY LITTLE SECONDARY STRUCTURE.
Salamanca, S., and Chang, J.-Y. (2006) The Protein Journal 25, 275-287.
Pathway of Oxidative Folding of a 3-Disulfide a-Lactalbumin May Resemble Either BPTI Model or Hirudin Model.
Lin, C.-J. and Chang, J.-Y. (2006) Biochemistry 45, 6231-6240.
Pathway of Oxidative Folding of Secretory Leucocyte Protease Inhibitor: AN 8-DISULFIDES PROTEIN EXHIBITS A UNIQUE MECHANISM OF FOLDING
Arolas, J. L., Aviles, F. X., Chang, J.-Y. and Ventura, S. (2006) Trends In Biochem. Sci. 31, 292-301.
Folding of small disulfide-rich proteins: clarifying the puzzle.
Braun, M. C., Li, L., Ke, B., Dubinsky, W. P., Pickering, M. C. and Chang, J.-Y. (2006) Nephrology 26, 127-135.
Proteomic profiling of urinary protein excretion in the factor H-deficient mouse.
Chang, J.-Y., Lu, B.-Y., C. C.-J. Lin., and C, Yu. (2006) FEBS Lett. 580, 656-660.
Fully Oxidized Scrambled Isomers Are Essential and Predominant Folding Intermediates of Cardiotoxin-III
Chang, J.-Y., Lu, B.-Y., and Lai, P.-H. (2006) Biochem. J. 394, 249-257.
Oxidative folding of hirudin in human serum
Lu, B.-Y. Jiang, C., and Chang, J.-Y. (2005) Biochemistry 44, 15032-15041.
Isomers of Epidermal Growth Factor with Ser_Cys Mutation At the N-terminal Sequence: ISOMERIZATION, STABILITY, UNFOLDING, REFOLDING and STRUCTURE
Jiang, C., and Chang, J.-Y. (2005) FEBS Lett. 579, 3927-3931.
Unfolding and breakdown of insulin in the presence of endogenous thiol
Chang, J.-Y., Lu, B.-Y., and Li, L. (2005) Analytical Biochemistry 342, 78-85.
Conformational impurity of disulfide proteins: Detection, quantification and properties
Chang, J.-Y., and Li, L. (2005) Arch. Biochem. Biophys. 437, 85-95.
Divergent folding pathways of two homologous proteins, BPTI and tick anticoagulant peptide
Lu, B.-Y., and Chang, J.-Y. (2005) Analytical Biochemistry 339, 94-103.
Assay of Disulfide Oxidase and Isomerase Based on The Model of Hirudin Folding
Salamanca, S., and Chang, J.-Y. (2005) Biochemistry 44, 744-750.
Unfolding and Refolding Pathways of A Major Kinetic Trap in The Oxidative Folding of a-Lactalbumin