Scott E. Wenderfer, M.D., Ph.D.
Assistant Professor
Center for Immunology & Autoimmune Diseases
Phone 713.500.2479;
Fax 713.500.2424
Scott.Wenderfer@uth.tmc.edu
Education:
M.D./Ph.D., University of Cincinnati College of Medicine, Cincinnati, Ohio
Pediatric Residency, University of Texas-Houston Medical School, Houston, Texas
Pediatric Nephrology Fellowship, University of Texas-Houston Medical School, Houston, Texas
Dr. Wenderfer received the Wulsin Fellowship for pre-doctoral research at the University of Cincinnati in 1996 and an NRSA training award in 2005 for fellowship research here at UT-Houston. He wrote his dissertation on "genomic analysis of antigen processing and the IL-4 cytokine family in the immune system" under the mentorship of Dr. John Monaco.
Dr. Wenderfer’s academic research interests are in the mechanisms of immune complex disease in the kidney. Immune complexes are antigen-antibody complexes that form in numerous infectious or autoimmune diseases. Immune complex diseases such as serum sickness, viral hepatitis, essential mixed cryoglobulinemia, overwhelming sepsis, chronic infections, IgA nephropathy, and systemic lupus erythematosus (SLE) are important causes of renal morbidity and mortality in children and adults. Human biopsy studies and ESRD registry data demonstrate that IC are present in the kidneys of 45-65% of patients with glomerulopathies. Understanding the renal responses to immune complexes will aid in the management of patients with these diseases. This would reduce the burden of end stage renal disease and avoid the need for dialysis in a significant set of patients.
Dr. Wenderfer's clinical interests include glomerulonephritis, tubular and interstitial nephritis, and renal manifestations of rheumatic diseases such as lupus erythematosus.
Dr. Wenderfer is a member of the American Academy of Pediatrics, the American Society of Pediatric Nephrology, the American Medical Association, the American Society of Nephrology, and the American Association of Immunologists.
Publications:
Scott E. Wenderfer, K. Soimo, R.A. Wetsel, M.C. Braun. The Role of C4 Binding Protein in a Mouse Model of Inflammatory Kidney Disease. Arthritis Research & Therapy 9:R114, 2008.
Scott E. Wenderfer, Rita D. Swinford, Shamila Mauiyyedi, David P. Witte, Michael C. Braun. Cytomegalovirus and Recurrent Idiopathic Membranoproliferative Glomerulonephritis Type 1: Cause or Consequence? Transplantation vol 83(4), 2007.
Scott E. Wenderfer, B. Ke, T.J. Hollman, H.Y. Lan, R.A. Wetsel, M.C. Braun. C5a Receptor Deficiency Attenuates T-cell Functions and Renal Disease in MRLlpr Mice. J Am Society Nephrology 16(12):3572-82, 2005.
Scott E. Wenderfer, John J. Monaco. Exon Trapping for Positional Cloning and Fingerprinting. Methods in Molecular Biology: Bacterial Artificial Chromosomes: Functional Studies. Vol 256, Shaying Zhao, Marvin Stodolsky, Ed., Humana Press, Totowa, New Jersey. pp7-20, 2004.
Scott E Wenderfer, James Nordlund. The Efficacy and Cost Effectiveness of Adjuvant IFNa2 Therapy for Surgically Resected Melanoma. University of Cincinnati Selected Student Papers: Efficient and Cost-Effective Clinical Decision Making. chapter 38, 1-13, 2000.
Scott E. Wenderfer, Jay P. Slack, T. Scott McCluskey, John J. Monaco. Identification of 40 Genes on a One Megabase Contig Around the IL-4 Cytokine Family Gene Cluster on Mouse Chromosome 11. Genomics 63(3):354-73, 2000.
Andres G. Grandea, Paul G. Comber, Scott E. Wenderfer, Gary Schoenhals, Klaus Fruh, John J. Monaco, Thomas Spies. Sequence, Linkage to H-2K, and Function of Mouse Tapasin in MHC Class I Assembly. Immunogenetics 48:260-5, 1998.