Salt taste responses of mouse chorda tympani neurons: Evidence for
existence of two different amiloride-sensitive receptor components for NaCl
with different temperature dependencies.
Department of Oral Physiology, Asahi University School of Dentistry,
Hozumi, Motosu, Gifu 501-02, Japan.
APStracts 3:0164N, 1996.
SUMMARY AND CONCLUSIONS
1. Inhibitory effects of amiloride on salt responses of single fibers of the
chorda tympani nerve of C57BL/6 strain of mice were examined at two different
temperatures (around 12 and 24 C). 2. Out of 36 single fibers that responded
to NaCl, 20 fibers showed strong suppression of responses to NaCl by lingual
treatment with amiloride (ami-sensitive fibers), whereas the remaining 16
fibers showed no such amiloride inhibition (ami-insensitive fibers). 3. Twenty
ami-sensitive fibers were further classified into two subgroups according to
the temperature dependency of their NaCl responses. In 15 out of 20 fibers,
amiloride inhibitable NaCl responses were larger at 24 C than at 12 C, whereas
the reverse was true for the remaining 5 fibers. All ami-insens - itive fibers
showed smaller responses to NaCl at 12 C. 4. These results suggest that there
exist two different amiloride- sensitive receptor components for NaCl with
different temperature dependencies in mouse taste cells: one is more sensitive
to NaCl at the higher temperature, and the other is more sensitive at the
Received 29 May 1996; accepted in final form 31 July 1996.
APS Manuscript Number J418-6.
Article publication pending J. Neurophysiol.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 29 August 1996